Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …

The finding that animals with circadian gene mutations exhibit diet-induced obesity and
metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain …

Liquid–liquid phase separation (LLPS) underlies diverse biological processes. Because
most LLPS studies were performed in vitro using recombinant proteins or in cells that …

Whether phase-separation is involved in the organization of the transcriptional machinery
and if it aids or inhibits the transcriptional process is a matter of intense debate. In this Mini …

Profound functional switch of key regulatory factors may play a major role in homeostasis
and disease. Dysregulation of circadian rhythm (CR) is strongly implicated in cancer with …

How the circadian nuclear orphan receptor REV-ERBα represses transcription: Temporal and
spatial phase separation combined: Molecular Cell Skip to Main Content Advertisement …

Cellular circadian clocks, the molecular timers that coordinate physiology to the day/night
cycle across the domains of life, are widely regulated by disordereddisordered protein …

JMJD1C, a member of the lysine demethylase 3 (KDM3) family, is universally required for
the survival of several types of acute myeloid leukemia (AML) cells with different genetic …

Circadian clocks have evolved to enable organisms to respond to daily environmental
changes. Maintaining a robust circadian rhythm under various perturbations and stresses is …

Circadian clocks drive a large array of physiological and behavioral activities. At the
molecular level, circadian clocks are composed of positive and negative elements that form …