Cholangiocarcinoma (CCA) is becoming more common and deadly worldwide. Tumor-
infiltrating T cell subtypes make distinct contributions to the immune system; collectively, they …

Neutrophils, which originate from the bone marrow and are characterized by a segmented
nucleus and a brief lifespan, have a crucial role in the body's defense against infections and …

Neutrophils, the most abundant and efficient defenders against pathogens, exert opposing
functions across cancer types. However, given their short half-life, it remains challenging to …

Abstract KRAS G12C mutations in non-small cell lung cancer (NSCLC) partially respond to
KRAS G12C covalent inhibitors. However, early adaptive resistance occurs due to rewiring …

The interleukin-1 receptor antagonist (IL-1Ra) is an anti-inflammatory cytokine and a
naturally occurring antagonist of the IL-1 receptor. It effectively counteracts the IL-1 signaling …

Aberrant RNA alternative splicing in cancer generates varied novel isoforms and protein
variants that facilitate cancer progression. Here, we employed the advanced long-read full …

The excision of introns from pre-mRNA is a crucial process in the expression of the majority
of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein …

Intrahepatic cholangiocarcinoma (iCCA) is the second most prevalent primary liver cancer.
Although the genetic characterization of iCCA has led to targeted therapies for treating …

The PD1/PD-L1 axis plays an important immunosuppressive role during the T-cell-mediated
immune response, which is essential for the physiological homeostasis of the immune …

Background The prognostic value and immune significance of T-cell proliferation regulators
(TCRs) in hepatocellular carcinoma (HCC) have not been previously reported. This study …