The choriocapillaris is the innermost structure of the choroid that directly nourishes the
retinal pigment epithelium and photoreceptors. This article provides an overview of its …

It has been known for over a century that the basic organization of the retina is conserved
across vertebrates. It has been equally clear that retinal cells can be classified into …

Up to 40% of patients with inflammatory bowel disease present with psychosocial
disturbances. We previously identified a gut vascular barrier that controls the dissemination …

Primary congenital glaucoma (PCG) is a severe disease characterized by developmental
defects in the trabecular meshwork (TM) and Schlemm's canal (SC), comprising the …

Subretinal fibrosis remains a major obstacle to the management of neovascular age-related
macular degeneration. Choroidal pericytes were found to be a significant source of …

Non-neuronal cells are key to the complex cellular interplay that follows central nervous
system insult. To understand this interplay, we generated a single-cell atlas of immune, glial …

The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of
chorioretinal diseases, many of which are poorly understood. Recent advances in the field of …

The human choroid is a heterogeneous, highly vascular connective tissue that dysfunctions
in age-related macular degeneration (AMD). In this study, we performed single-cell RNA …

Injuries to the retinal pigment epithelium (RPE) and outer retina often result in the
accumulation of retinal microglia within the subretinal space. These subretinal microglia play …

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare disease caused by the
expression of progerin, an aberrant protein produced by a point mutation in the LMNA gene …