Interplay between inflammation and thrombosis in cardiovascular pathology
Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …
death worldwide, making it a major health-care challenge. Platelets and the coagulation …
[HTML][HTML] Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses
Viruses that replicate in the human respiratory mucosa without infecting systemically,
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …
Map** the human genetic architecture of COVID-19
Writing group Writing group leaders Pathak Gita A. 6 … - Nature, 2021 - nature.com
The genetic make-up of an individual contributes to the susceptibility and response to viral
infection. Although environmental, clinical and social factors have a role in the chance of …
infection. Although environmental, clinical and social factors have a role in the chance of …
[HTML][HTML] Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
To the Editor—We report the kinetics of immune responses in relation to clinical and
virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) …
virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) …
Platelet gene expression and function in patients with COVID-19
BK Manne, F Denorme, EA Middleton… - Blood, The Journal …, 2020 - ashpublications.org
There is an urgent need to understand the pathogenesis of coronavirus disease 2019
(COVID-19). In particular, thrombotic complications in patients with COVID-19 are common …
(COVID-19). In particular, thrombotic complications in patients with COVID-19 are common …
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …
[HTML][HTML] Type I interferons in infectious disease
Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …
Interferon-stimulated genes: a complex web of host defenses
Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …
they are highly effective at resisting and controlling pathogens. In this review, we begin by …
γ-Secretase in Alzheimer's disease
JY Hur - Experimental & molecular medicine, 2022 - nature.com
Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …
The COVID-19 host genetics initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic
COVID-19 Host Genetics Initiative aganna … - European Journal of …, 2020 - nature.com
The COVID-19 pandemic is a global crisis creating severe disruptions across the economy
and health system. Insights into how to better understand and treat COVID-19 are …
and health system. Insights into how to better understand and treat COVID-19 are …