Pediatric low-grade glioma in the era of molecular diagnostics
Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …
spectrum of histologic entities which are currently assigned World Health Organisation …
MAPK pathway activation in pilocytic astrocytoma
Pilocytic astrocytoma (PA) is the most common tumor of the pediatric central nervous system
(CNS). A body of research over recent years has demonstrated a key role for mitogen …
(CNS). A body of research over recent years has demonstrated a key role for mitogen …
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
Nature genetics, 2013 - nature.com
The most common pediatric brain tumors are low-grade gliomas (LGGs). We used whole-
genome sequencing to identify multiple new genetic alterations involving BRAF, RAF1 …
genome sequencing to identify multiple new genetic alterations involving BRAF, RAF1 …
BRAF Mutation and CDKN2A Deletion Define a Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma
Purpose To uncover the genetic events leading to transformation of pediatric low-grade
glioma (PLGG) to secondary high-grade glioma (sHGG). Patients and Methods We …
glioma (PLGG) to secondary high-grade glioma (sHGG). Patients and Methods We …
BRAF-KIAA1549 Fusion Predicts Better Clinical Outcome in Pediatric Low-Grade Astrocytoma
Purpose: Recent studies have revealed that the majority of pediatric low-grade astrocytomas
(PLGA) harbor the BRAF-KIAA1549 (BK) fusion gene resulting in constitutive activation of …
(PLGA) harbor the BRAF-KIAA1549 (BK) fusion gene resulting in constitutive activation of …
Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features
Diffuse leptomeningeal glioneuronal tumors (DLGNT) represent rare CNS neoplasms which
have been included in the 2016 update of the WHO classification. The wide spectrum of …
have been included in the 2016 update of the WHO classification. The wide spectrum of …
Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1
LA Ramkissoon, PM Horowitz… - Proceedings of the …, 2013 - National Acad Sciences
Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children
but, apart from BRAF kinase mutations or duplications in specific subclasses, few genetic …
but, apart from BRAF kinase mutations or duplications in specific subclasses, few genetic …
Clinicopathological relevance of BRAF mutations in human cancer
S Pakneshan, A Salajegheh, RA Smith… - Pathology-Journal of …, 2013 - journals.lww.com
BRAF represents one of the most frequently mutated protein kinase genes in human
tumours. The mutation is commonly tested in pathology practice. BRAF mutation is seen in …
tumours. The mutation is commonly tested in pathology practice. BRAF mutation is seen in …
The oncogenic fusion landscape in pediatric CNS neoplasms
Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-
related deaths in children. Recent developments in molecular analyses have greatly …
related deaths in children. Recent developments in molecular analyses have greatly …
Pleomorphic xanthoastrocytoma: a brief review
Pleomorphic xanthoastrocytoma (PXA) is a rare primary CNS tumor. Recent advances in the
molecular characterization are hel** to define subtypes of tumor. The discovery of BRAF …
molecular characterization are hel** to define subtypes of tumor. The discovery of BRAF …