Several lines of evidence have indicated that depression might be a prodromal symptom of
Alzheimer's disease (AD). This systematic review and meta-analysis investigated the cross …

Alzheimer's disease (AD) is considered a continuum, progressing from preclinical disease to
mild cognitive impairment (MCI) as an early stage, before reaching clinically apparent …

Abstract Background Current AT (N) stratification for Alzheimer's disease (AD) accounts for
complex combinations of amyloid (A), tau proteinopathy (T) and neurodegeneration (N) …

Background Alzheimer's disease (AD) diagnosis relies on clinical symptoms complemented
with biological biomarkers, the Amyloid Tau Neurodegeneration (ATN) framework. Small …

Depression is usually accompanied with cognitive impairment and increases risk of incident
dementia. However, evidence has been limited on the effect size of depression with …

Background Substantial evidence supports the relationship between peripheral insulin
resistance (IR) and the development of Alzheimer's disease (AD)-dementia. However, the …

Despite the central role attributed to neuroinflammation in the etiology and pathobiology of
Alzheimer's disease (AD), the direct link between levels of inflammatory mediators in blood …

Background The high heterogeneity of neuropsychiatric symptoms (NPSs) hinders further
exploration of their role in neurobiological mechanisms and Alzheimer's disease (AD). We …

Mild cognitive impairment (MCI) is an intermediate stage between normal aging and
dementia, and a significant number of individuals with MCI progress to develop dementia …

The novel amyloid-beta, p-Tau, and neurofilament light chain (ATN) classification scheme
has become a promising system for clinically detecting and diagnosing Alzheimer's disease …