Biochemical and biological attributes of matrix metalloproteinases

N Cui, M Hu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …

The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review

ESE Mehana, AF Khafaga, SS El-Blehi - Life sciences, 2019 - Elsevier
Extensive degeneration of articular cartilage (AC) is a primary event in the pathogenesis of
osteoarthritis (OA) and other types of joint and bone inflammation. OA results in the loss of …

Dental enamel formation and implications for oral health and disease

RS Lacruz, S Habelitz, JT Wright… - Physiological …, 2017 - journals.physiology.org
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Regulation of matrix metalloproteinase expression in tumor invasion

J Westermarck, VM Kähäri - The FASEB journal, 1999 - Wiley Online Library
Degradation of basement membranes and stromal extracellular matrix (ECM) is crucial for
invasion and metastasis of malignant cells. Degradation of ECM is initiated by proteinases …

Matrix metalloproteinases and metastasis

DE Kleiner, WG Stetler-Stevenson - Cancer chemotherapy and …, 1999 - Springer
Metastatic disease is responsible for the majority of cancer-related deaths, either directly
due to tumor involvement of critical organs or indirectly due to complications of therapy to …

Matrix metalloproteinases in the brain and blood–brain barrier: versatile breakers and makers

RG Rempe, AMS Hartz, B Bauer - Journal of Cerebral Blood …, 2016 - journals.sagepub.com
Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Matrix metalloproteinases: structures, evolution, and diversification

I Massova, LP Kotra, R Fridman… - The FASEB …, 1998 - Wiley Online Library
ABSTRACT A comprehensive sequence alignment of 64 members of the family of matrix
metalloproteinases (MMPs) for the entire sequences, and subsequently the catalytic and the …

Cellular and chemical events during enamel maturation

CE Smith - Critical Reviews in Oral Biology & Medicine, 1998 - journals.sagepub.com
This review focuses on the process of enamel maturation, a series of events associated with
slow, progressive growth in the width and thickness of apatitic crystals. This developmental …

[HTML][HTML] Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models

M Fanjul-Fernández, AR Folgueras, S Cabrera… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play
important roles in multiple physiological and pathological processes. These enzymes are …