D‐lactic acid as a metabolite: toxicology, diagnosis, and detection
M Pohanka - BioMed Research International, 2020 - Wiley Online Library
Two enantiomers of lactic acid exist. While L‐lactic acid is a common compound of human
metabolism, D‐lactic acid is produced by some strains of microorganism or by some less …
metabolism, D‐lactic acid is produced by some strains of microorganism or by some less …
Bacterial responses to glyoxal and methylglyoxal: reactive electrophilic species
C Lee, C Park - International journal of molecular sciences, 2017 - mdpi.com
Glyoxal (GO) and methylglyoxal (MG), belonging to α-oxoaldehydes, are produced by
organisms from bacteria to humans by glucose oxidation, lipid peroxidation, and DNA …
organisms from bacteria to humans by glucose oxidation, lipid peroxidation, and DNA …
Presence of unique glyoxalase III proteins in plants indicates the existence of shorter route for methylglyoxal detoxification
Glyoxalase pathway, comprising glyoxalase I (GLY I) and glyoxalase II (GLY II) enzymes, is
the major pathway for detoxification of methylglyoxal (MG) into D-lactate involving reduced …
the major pathway for detoxification of methylglyoxal (MG) into D-lactate involving reduced …
DJ‐1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons
Human DJ‐1 is a cytoprotective protein whose absence causes Parkinson's disease and is
also associated with other diseases. DJ‐1 has an established role as a redox‐regulated …
also associated with other diseases. DJ‐1 has an established role as a redox‐regulated …
[HTML][HTML] 2-Hydroxy acids in plant metabolism
Abstract Glycolate, malate, lactate, and 2-hydroxyglutarate are important 2-hydroxy acids
(2HA) in plant metabolism. Most of them can be found as D-and L-stereoisomers. These …
(2HA) in plant metabolism. Most of them can be found as D-and L-stereoisomers. These …
The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals
A Andreeva, Z Bekkhozhin, N Omertassova… - Journal of Biological …, 2019 - ASBMB
Loss-of-function mutations in the gene encoding human protein DJ-1 cause early onset of
Parkinson's disease, suggesting that DJ-1 protects dopaminergic neurons. The molecular …
Parkinson's disease, suggesting that DJ-1 protects dopaminergic neurons. The molecular …
Chemical toolkit for PARK7: potent, selective, and high-throughput
The multifunctional human Parkinson's disease protein 7 (PARK7/DJ1) is an attractive
therapeutic target due to its link with early-onset Parkinson's disease, upregulation in …
therapeutic target due to its link with early-onset Parkinson's disease, upregulation in …
Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro
DJ-1 (also known as PARK7) has been identified as a causal gene for hereditary recessive
Parkinson's disease (PD). Consequently, the full elucidation of DJ-1 function will help …
Parkinson's disease (PD). Consequently, the full elucidation of DJ-1 function will help …
Parkinsonism-associated protein DJ-1 is an antagonist, not an eraser, for protein glycation
Q Gao, JW Jacob-Dolan, RA Scheck - Biochemistry, 2023 - ACS Publications
Advanced glycation end-products (AGEs) are irreversible protein modifications that are
strongly associated with aging and disease. Recently, the Parkinsonism-associated protein …
strongly associated with aging and disease. Recently, the Parkinsonism-associated protein …
Comparative analysis of glyoxalase pathway genes in Erianthus arundinaceus and commercial sugarcane hybrid under salinity and drought conditions
Background Glyoxalase pathway is a reactive carbonyl species (RCS) scavenging
mechanism involved in the detoxification of methylglyoxal (MG), which is a reactive α …
mechanism involved in the detoxification of methylglyoxal (MG), which is a reactive α …