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Small molecules in the treatment of COVID-19
S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
Anthelmintic nitazoxanide protects against experimental pulmonary fibrosis
XY Chen, YC Dong, YY Yu, M Jiang… - British Journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose Nitazoxanide is a therapeutic anthelmintic drug. Our
previous studies found that nitazoxanide and its metabolite tizoxanide activated adenosine …
previous studies found that nitazoxanide and its metabolite tizoxanide activated adenosine …
[HTML][HTML] SARS-CoV-2 variants evolve convergent strategies to remodel the host response
SARS-CoV-2 variants of concern (VOCs) emerged during the COVID-19 pandemic. Here,
we used unbiased systems approaches to study the host-selective forces driving VOC …
we used unbiased systems approaches to study the host-selective forces driving VOC …
Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories
ABSTRACT A series of SARS-CoV-2 variants of concern (VOCs) have evolved in humans
during the COVID-19 pandemic—Alpha, Beta, Gamma, Delta, and Omicron. Here, we used …
during the COVID-19 pandemic—Alpha, Beta, Gamma, Delta, and Omicron. Here, we used …
The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoprotein
S Piacentini, A Riccio, S Santopolo… - Frontiers in …, 2023 - frontiersin.org
Coronaviridae is recognized as one of the most rapidly evolving virus family as a
consequence of the high genomic nucleotide substitution rates and recombination. The …
consequence of the high genomic nucleotide substitution rates and recombination. The …
Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single-cell RNA sequencing
Single-cell RNA sequencing (scRNA-Seq) studies have provided critical insight into the
pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the …
pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the …
CNBP restricts SARS-CoV2 by regulating IFN and disrupting RNA-protein condensates
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades antiviral immunity
through the expression of viral proteins that block detection, signaling, interferon (IFN) …
through the expression of viral proteins that block detection, signaling, interferon (IFN) …
Antiviral effect of thiazolides relies on mitochondrial mild uncoupling
Background Viruses are dependent on cellular energy metabolism for their replication, the
drug Nitazoxanide (Alinia) was shown to interfere with both. An effect of Alinia on cellular …
drug Nitazoxanide (Alinia) was shown to interfere with both. An effect of Alinia on cellular …
Can Nitazoxanide and/or other anti‐viral medications be a solution to long COVID? Case report with a brief literature review
Key Clinical Message Findings here imply lingering of virus, SARS‐CoV‐2, in the body for
months. Thus, Nitazoxanide and/or other anti‐viral medications might be potential options to …
months. Thus, Nitazoxanide and/or other anti‐viral medications might be potential options to …