Background Nowadays, conventional medical treatments such as surgery, radiotherapy, and
chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is …

Radiopharmaceuticals are rapidly develo** as a field, with the successful use of targeted
beta emitters in neuroendocrine tumors and prostate cancer serving as catalysts. Targeted …

Skin cancer is a critical global public health concern, with melanoma being the deadliest
variant, correlated to 80% of skin cancer-related deaths and a remarkable propensity to …

Melanoma is an aggressive kind of skin cancer; its rate has risen rapidly over the past few
decades. Melanoma reports for only about 1% of skin cancers but leads to a high majority of …

The role of phosphatase and tensin homolog on chromosome 10 (PTEN) as a tumor
suppressor has been for a long time attributed to its lipid phosphatase activity against PI (3 …

Melanocortins play crucial roles in regulating the stress response, inflammation, and skin
pigmentation. In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein …

Cancer is one of the leading causes of death worldwide. The development of cancer-specific
diagnostic agents and anticancer toxins would improve patient survival. The current and …

Alpha-melanocyte stimulating hormone (α-MSH) and its receptor, melanocortin 1 receptor
(MC1R), have been proposed as potential target for anti-cancer strategies in melanoma …

Melanocortins are peptide hormones critical for the regulation of stress response, energy
homeostasis, inflammation, and skin pigmentation. Their functions are mediated by five G …

G-protein coupled receptors (GPCRs), which include melanocortin-1 receptor (MC1R), play
a crucial role in melanocytes development, proliferation and differentiation. Activation of the …