Antiviral and antimicrobial nucleoside derivatives: structural features and mechanisms of action

AA Zenchenko, MS Drenichev, IA Il'Icheva… - Molecular biology, 2021 - Springer
The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …

Recent trends in praziquantel nanoformulations for helminthiasis treatment

AC Mengarda, B Iles, JP F. Longo… - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Infections caused by parasitic flatworms impose a considerable worldwide
health burden. Recently, World Health Organization launched its roadmap for neglected …

Organoselenium compounds in medicinal chemistry

C Gallo‐Rodriguez, JB Rodriguez - ChemMedChem, 2024 - Wiley Online Library
The chemical and biological interest in this element and the molecules bearing selenium
has been exponentially growing over the years. Selenium, formerly designated as a toxin …

Therapeutic efficacy of carvacrol-loaded nanoemulsion in a mouse model of schistosomiasis

ES Xavier, RL de Souza, VC Rodrigues… - Frontiers in …, 2022 - frontiersin.org
Since praziquantel is the only drug available to treat schistosomiasis, a neglected parasitic
disease that affects more than 240 million people worldwide, there is an urgent demand for …

Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties

JA Rocha, NCS Rego, BTS Carvalho, FI Silva… - PloS one, 2018 - journals.plos.org
Schistosomiasis affects million people and its control is widely dependent on a single drug,
praziquantel. Computational chemistry has led to the development of new tools that predict …

Brazilian red propolis exhibits antiparasitic properties in vitro and reduces worm burden and egg production in an mouse model harboring either early or chronic …

MP Silva, TM Silva, AC Mengarda, MC Salvadori… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Propolis has been used in folk medicine for thousands of
years and, in the past few decades, it has attracted renewed interest. Although propolis has …

Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis

AC Mengarda, PS Mendonca, CS Morais, RM Cogo… - Acta tropica, 2020 - Elsevier
Schistosomiasis is one of the most important parasitic infections in terms of its negative
effects on public health and economics. Since praziquantel is currently the only drug …

[HTML][HTML] Nifuroxazide Prevents Chikungunya Virus Infection Both In Vitro and In Vivo via Suppressing Viral Replication

Y Liu, M Xu, B **a, Z Qiao, Y He, Y Liu, Z Pan, C Zhang… - Viruses, 2024 - mdpi.com
Chikungunya virus (CHIKV) is a reemerging arbovirus causing disease on a global scale,
and the potential for its epidemics remains high. CHIKV has caused millions of cases and …

Pyrazoline derivatives as promising novel antischistosomal agents

CS Morais, AC Mengarda, FB Miguel, KB Enes… - Scientific Reports, 2021 - nature.com
Praziquantel is the only available drug to treat schistosomiasis, a parasitic disease that
currently infects more than 240 million people globally. Due to increasing concerns about …

Licarin A, a neolignan isolated from Nectandra oppositifolia Nees & Mart. (Lauraceae), exhibited moderate preclinical efficacy against Schistosoma mansoni …

AC Mengarda, MP Silva, ME Cirino… - Phytotherapy …, 2021 - Wiley Online Library
Schistosomiasis is a widespread human parasitic disease currently affecting over 200
million people, particularly in poor communities. Chemotherapy for schistosomiasis relies …