Antiviral and antimicrobial nucleoside derivatives: structural features and mechanisms of action
AA Zenchenko, MS Drenichev, IA Il'Icheva… - Molecular biology, 2021 - Springer
The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …
Recent trends in praziquantel nanoformulations for helminthiasis treatment
AC Mengarda, B Iles, JP F. Longo… - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Infections caused by parasitic flatworms impose a considerable worldwide
health burden. Recently, World Health Organization launched its roadmap for neglected …
health burden. Recently, World Health Organization launched its roadmap for neglected …
Organoselenium compounds in medicinal chemistry
C Gallo‐Rodriguez, JB Rodriguez - ChemMedChem, 2024 - Wiley Online Library
The chemical and biological interest in this element and the molecules bearing selenium
has been exponentially growing over the years. Selenium, formerly designated as a toxin …
has been exponentially growing over the years. Selenium, formerly designated as a toxin …
Therapeutic efficacy of carvacrol-loaded nanoemulsion in a mouse model of schistosomiasis
ES Xavier, RL de Souza, VC Rodrigues… - Frontiers in …, 2022 - frontiersin.org
Since praziquantel is the only drug available to treat schistosomiasis, a neglected parasitic
disease that affects more than 240 million people worldwide, there is an urgent demand for …
disease that affects more than 240 million people worldwide, there is an urgent demand for …
Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties
JA Rocha, NCS Rego, BTS Carvalho, FI Silva… - PloS one, 2018 - journals.plos.org
Schistosomiasis affects million people and its control is widely dependent on a single drug,
praziquantel. Computational chemistry has led to the development of new tools that predict …
praziquantel. Computational chemistry has led to the development of new tools that predict …
Brazilian red propolis exhibits antiparasitic properties in vitro and reduces worm burden and egg production in an mouse model harboring either early or chronic …
MP Silva, TM Silva, AC Mengarda, MC Salvadori… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Propolis has been used in folk medicine for thousands of
years and, in the past few decades, it has attracted renewed interest. Although propolis has …
years and, in the past few decades, it has attracted renewed interest. Although propolis has …
Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis
Schistosomiasis is one of the most important parasitic infections in terms of its negative
effects on public health and economics. Since praziquantel is currently the only drug …
effects on public health and economics. Since praziquantel is currently the only drug …
[HTML][HTML] Nifuroxazide Prevents Chikungunya Virus Infection Both In Vitro and In Vivo via Suppressing Viral Replication
Y Liu, M Xu, B **a, Z Qiao, Y He, Y Liu, Z Pan, C Zhang… - Viruses, 2024 - mdpi.com
Chikungunya virus (CHIKV) is a reemerging arbovirus causing disease on a global scale,
and the potential for its epidemics remains high. CHIKV has caused millions of cases and …
and the potential for its epidemics remains high. CHIKV has caused millions of cases and …
Pyrazoline derivatives as promising novel antischistosomal agents
CS Morais, AC Mengarda, FB Miguel, KB Enes… - Scientific Reports, 2021 - nature.com
Praziquantel is the only available drug to treat schistosomiasis, a parasitic disease that
currently infects more than 240 million people globally. Due to increasing concerns about …
currently infects more than 240 million people globally. Due to increasing concerns about …
Licarin A, a neolignan isolated from Nectandra oppositifolia Nees & Mart. (Lauraceae), exhibited moderate preclinical efficacy against Schistosoma mansoni …
AC Mengarda, MP Silva, ME Cirino… - Phytotherapy …, 2021 - Wiley Online Library
Schistosomiasis is a widespread human parasitic disease currently affecting over 200
million people, particularly in poor communities. Chemotherapy for schistosomiasis relies …
million people, particularly in poor communities. Chemotherapy for schistosomiasis relies …