Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …

Simple Summary Accumulating evidence indicates that hypoxia-inducible factor-1 (HIF-1)
plays a pivotal role in tumor biology, particularly in hypoxic environments. Over the past few …

Acidic metabolic waste products accumulate in the tumor microenvironment because of high
metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and …

There is a growing demand for develo** wearable sensors that can non-invasively detect
the signs of chronic diseases early on to possibly enable self-health management. Among …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

The salt bridge is the strongest non-covalent interaction in nature and is known to participate
in protein folding, protein-protein interactions, and molecular recognition. However, the role …

Implantable chemical sensors built with flexible and biodegradable materials exhibit
immense potential for seamless integration with biological systems by matching the …

Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …

The intracellular pH (pHi) in organelles, including mitochondria, endoplasmic reticulum,
lysosomes, and nuclei, differs from the cytoplasmic pH, and thus maintaining the pH of these …

Stable mechanical properties under cyclic mechanical loads are critical for the applications
of hydrogels in flexible electronics and tissue engineering. However, most existing tough …