Efferocytosis and its role in inflammatory disorders

Y Ge, M Huang, Y Yao - Frontiers in cell and developmental biology, 2022‏ - frontiersin.org
Efferocytosis is the effective clearance of apoptotic cells by professional and non-
professional phagocytes. The process is mechanically different from other forms of …

[HTML][HTML] Role of transglutaminase 2 in cell death, survival, and fibrosis

H Tatsukawa, K Hitomi - Cells, 2021‏ - mdpi.com
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the crosslinking
between Gln and Lys residues and involved in various pathophysiological events. Besides …

Non-classical ferroptosis inhibition by a small molecule targeting PHB2

W Yang, B Mu, J You, C Tian, H Bin, Z Xu… - Nature …, 2022‏ - nature.com
Ferroptosis is a new type of programmed cell death characterized by iron-dependent lipid
peroxidation. Ferroptosis inhibition is thought as a promising therapeutic strategy for a …

The ABCA1-efferocytosis axis: A new strategy to protect against atherosclerosis

W Chen, L Li, J Wang, R Zhang, T Zhang, Y Wu… - Clinica Chimica …, 2021‏ - Elsevier
Atherosclerosis, a disease process characterized by lipid accumulation and inflammation, is
the main cause of coronary heart disease (CHD) and myocardial infarction (MI) …

Update of cellular responses to the efferocytosis of necroptosis and pyroptosis

CA Purnama, A Meiliana, MI Barliana, K Lestari - Cell Division, 2023‏ - Springer
Cell death is a basic physiological process that occurs in all living organisms. A few key
players in these mechanisms, as well as various forms of cell death programming, have …

FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE−/− mice atherosclerosis

L Xu, H Zhang, Y Wang, A Yang, X Dong, L Gu… - Laboratory …, 2022‏ - nature.com
Atherosclerosis is a chronic inflammatory vascular disease, and inflammation plays a critical
role in its formation and progression. Elevated serum homocysteine (Hcy) is an independent …

Alendronate crosslinked chitosan/polycaprolactone scaffold for bone defects repairing

W Shi, X Zhang, L Bian, Y Dai, Z Wang, Y Zhou… - International Journal of …, 2022‏ - Elsevier
Here, we evaluated osteogenic differentiation in vitro and new bone formation in vivo using
an alendronate-loaded chitosan/polycaprolactone scaffold (CS/PCL) in rats with a critical …

Dynamic chromatin architecture of the porcine adipose tissues with weight gain and loss

L **, D Wang, J Zhang, P Liu, Y Wang, Y Lin… - Nature …, 2023‏ - nature.com
Using an adult female miniature pig model with diet-induced weight gain/weight loss, we
investigated the regulatory mechanisms of three-dimensional (3D) genome architecture in …

[HTML][HTML] Cellular and molecular mechanisms and effects of berberine on obesity-induced inflammation

JW Noh, MS Jun, HK Yang, BC Lee - Biomedicines, 2022‏ - mdpi.com
Obesity represents chronic low-grade inflammation that precipitates type 2 diabetes,
cardiovascular disease, and cancer. Berberine (BBR) has been reported to exert anti …

[HTML][HTML] The biological and biomechanical role of transglutaminase-2 in the tumour microenvironment

R Tempest, S Guarnerio, R Maani, J Cooper, N Peake - Cancers, 2021‏ - mdpi.com
Simple Summary Transglutaminase-2 (TG2) is an enzyme primarily involved in protein cross-
linking, which has been shown to play a role in the development and progression of …