The broken cycle: E2F dysfunction in cancer
The cyclin-dependent kinase (CDK)–RB–E2F axis forms the core transcriptional machinery
driving cell cycle progression, dictating the timing and fidelity of genome replication and …
driving cell cycle progression, dictating the timing and fidelity of genome replication and …
Control of cell cycle transcription during G1 and S phases
The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …
The DREAM complex: master coordinator of cell cycle-dependent gene expression
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F …
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F …
Cell cycle regulation in plant development
Cell cycle regulation is of pivotal importance for plant growth and development. Although
plant cell division shares basic mechanisms with all eukaryotes, plants have evolved novel …
plant cell division shares basic mechanisms with all eukaryotes, plants have evolved novel …
Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a …
JH Alexander - JAMA: Journal of the American Medical …, 2005 - search.ebscohost.com
Context Coronary artery bypass graft (CABG) surgery with autologous vein grafting is
commonly performed. Progressive neointimal hyperplasia, however, contributes to …
commonly performed. Progressive neointimal hyperplasia, however, contributes to …
Thymidine kinase 1 through the ages: a comprehensive review
EE Bitter, MH Townsend, R Erickson, C Allen… - Cell & bioscience, 2020 - Springer
Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and
thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in …
thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in …
Polyploidy in tissue homeostasis and regeneration
Polyploid cells, which contain multiple copies of the typically diploid genome, are
widespread in plants and animals. Polyploidization can be developmentally programmed or …
widespread in plants and animals. Polyploidization can be developmentally programmed or …
Distinct and overlap** roles for E2F family members in transcription, proliferation and apoptosis
Since the discovery almost fifteen years ago that E2F transcription factors are key targets of
the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the …
the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the …
Control of the G2/M transition
The G 2 checkpoint prevents cells from entering mitosis when DNA is damaged, providing
an opportunity for repair and stop** the proliferation of damaged cells. Because the G 2 …
an opportunity for repair and stop** the proliferation of damaged cells. Because the G 2 …
[HTML][HTML] A comprehensive review of the roles of E2F1 in colon cancer
Abstract E2F transcription factor 1 (E2F1) is a member of the E2F family of transcription
factors. E2F1 binds to DNA with dimerization partner (DP) proteins through an E2 …
factors. E2F1 binds to DNA with dimerization partner (DP) proteins through an E2 …