Invadopodia are a subset of invadosomes that are implicated in the integration of signals
from the tumor microenvironment to support tumor cell invasion and dissemination. Recent …

The process of entering the bloodstream, intravasation, is a necessary step in the
development of distant metastases. The focus of this review is on the pathways and …

Breast cancer cells disseminate through TIE2/MENACalc/MENAINV-dependent cancer cell
intravasation sites, called tumor microenvironment of metastasis (TMEM), which are …

Dissemination of tumor cells is an essential step in metastasis. Direct contact between a
macrophage, mammalian-enabled (MENA)–overexpressing tumor cell, and endothelial cell …

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an
essential component of tumour dissemination during progression and metastasis. This …

Metastasis requires tumor cell dissemination to different organs from the primary tumor.
Dissemination is a complex cell motility phenomenon that requires the molecular …

Metastases are initiated by disseminated tumor cells (DTCs) that colonize distant organs.
Growing evidence suggests that the microenvironment of the primary tumor primes DTCs for …

Cell migration controls developmental processes (gastrulation and tissue patterning), tissue
homeostasis (wound repair and inflammatory responses), and the pathobiology of diseases …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Fibronectin (FN) is a major component of the tumor microenvironment, but its role in
promoting metastasis is incompletely understood. Here, we show that FN gradients elicit …