The role of protein loops and linkers in conformational dynamics and allostery
Proteins are dynamic entities that undergo a plethora of conformational changes that may
take place on a wide range of time scales. These changes can be as small as the rotation of …
take place on a wide range of time scales. These changes can be as small as the rotation of …
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in …
CD Putnam, M Hammel, GL Hura… - Quarterly reviews of …, 2007 - cambridge.org
Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …
analyses; however, it is restricted to describing low energy conformations of …
NMR probes of molecular dynamics: overview and comparison with other techniques
AG Palmer III - Annual review of biophysics and biomolecular …, 2001 - annualreviews.org
▪ Abstract NMR spin relaxation spectroscopy is a powerful approach for characterizing
intramolecular and overall rotational motions in proteins. This review describes experimental …
intramolecular and overall rotational motions in proteins. This review describes experimental …
Macromolecular diffractive imaging using imperfect crystals
The three-dimensional structures of macromolecules and their complexes are mainly
elucidated by X-ray protein crystallography. A major limitation of this method is access to …
elucidated by X-ray protein crystallography. A major limitation of this method is access to …
One hundred years of diffuse scattering
TR Welberry, T Weber - Crystallography Reviews, 2016 - Taylor & Francis
Over the 100 years since the discovery of the diffraction of X-rays by crystals, structure
determination based on the analysis of Bragg peaks has grown into a very precise, widely …
determination based on the analysis of Bragg peaks has grown into a very precise, widely …
X-ray scattering studies of protein structural dynamics
X-ray scattering is uniquely suited to the study of disordered systems and thus has the
potential to provide insight into dynamic processes where diffraction methods fail. In …
potential to provide insight into dynamic processes where diffraction methods fail. In …
Map** enzyme landscapes by time-resolved crystallography with synchrotron and x-ray free electron laser light
MA Wilson - Annual review of biophysics, 2022 - annualreviews.org
Directly observing enzyme catalysis in real time at the molecular level has been a long-
standing goal of structural enzymology. Time-resolved serial crystallography methods at …
standing goal of structural enzymology. Time-resolved serial crystallography methods at …
Diffuse X-ray scattering from correlated motions in a protein crystal
Protein dynamics are integral to biological function, yet few techniques are sensitive to
collective atomic motions. A long-standing goal of X-ray crystallography has been to …
collective atomic motions. A long-standing goal of X-ray crystallography has been to …
Motions of calmodulin characterized using both Bragg and diffuse X-ray scattering
Background: Calmodulin is a calcium-activated regulatory protein which can bind to many
different targets. The protein resembles a highly flexible dumbbell, and bends in the middle …
different targets. The protein resembles a highly flexible dumbbell, and bends in the middle …
Temperature dependence of the internal dynamics of a calmodulin− peptide complex
The temperature dependence of the fast internal dynamics of calcium-saturated calmodulin
in complex with a peptide corresponding to the calmodulin-binding domain of the smooth …
in complex with a peptide corresponding to the calmodulin-binding domain of the smooth …