An epidemic of obesity has affected large portions of the world, increasing the risk of
develo** many different age-associated diseases, including cancer, cardiovascular …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

It has long been postulated that dietary restriction is beneficial for ensuring longevity and
extending the health span of mammals, including humans. In particular, a reduction in …

Cellular senescence, a process in which a cell exits the cell cycle in response to stressors, is
one of the hallmarks of aging. Senescence and the senescence-associated secretory …

Patients with diabetes require daily medication to maintain blood sugar levels. Nevertheless,
the long-term use of antidiabetics can lose efficacy and cause degeneration in some …

Elevated levels of circulating branched-chain amino acids (BCAAs) and their associated
metabolites have been strongly linked to insulin resistance and type 2 diabetes. Despite …

The adverse metabolic impacts of branched-chain amino acids (BCAA) have been
elucidated are mediated by isoleucine and valine. Dietary restriction of isoleucine promotes …

Dietary protein intake modulates growth, reproduction, and longevity by stimulating amino
acid (AA)–sensing pathways. Essential AAs are often considered as limiting nutrients during …

Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are
associated with healthy aging in humans, and dietary protein restriction extends the lifespan …

Life activities are supported by the intricate metabolic network that is fueled by nutrients.
Nutritional and genetic studies in model organisms have determined that dietary restriction …