Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience

JP Kesby, DW Eyles, JJ McGrath, JG Scott - Translational psychiatry, 2018 - nature.com
The stagnation in drug development for schizophrenia highlights the need for better
translation between basic and clinical research. Understanding the neurobiology of …

Stress weakens prefrontal networks: molecular insults to higher cognition

AFT Arnsten - Nature neuroscience, 2015 - nature.com
A variety of cognitive disorders are worsened by stress exposure and involve dysfunction of
the newly evolved prefrontal cortex (PFC). Exposure to acute, uncontrollable stress …

Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine

R Cools, AFT Arnsten - Neuropsychopharmacology, 2022 - nature.com
The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

[HTML][HTML] The effects of stress exposure on prefrontal cortex: Translating basic research into successful treatments for post-traumatic stress disorder

AFT Arnsten, MA Raskind, FB Taylor, DF Connor - Neurobiology of stress, 2015 - Elsevier
Research on the neurobiology of the stress response in animals has led to successful new
treatments for Post-Traumatic Stress Disorder (PTSD) in humans. Basic research has found …

Inverted-U–shaped dopamine actions on human working memory and cognitive control

R Cools, M D'Esposito - Biological psychiatry, 2011 - Elsevier
Brain dopamine (DA) has long been implicated in cognitive control processes, including
working memory. However, the precise role of DA in cognition is not well-understood, partly …

Stress signalling pathways that impair prefrontal cortex structure and function

AFT Arnsten - Nature reviews neuroscience, 2009 - nature.com
The prefrontal cortex (PFC)—the most evolved brain region—subserves our highest-order
cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental …

The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity.

CB Holroyd, MGH Coles - Psychological review, 2002 - psycnet.apa.org
The authors present a unified account of 2 neural systems concerned with the development
and expression of adaptive behaviors: a mesencephalic dopamine system for reinforcement …

Effects of a secure attachment relationship on right brain development, affect regulation, and infant mental health

AN Schore - Infant mental health journal: official publication of …, 2001 - Wiley Online Library
Over the last ten years the basic knowledge of brain structure and function has vastly
expanded, and its incorporation into the developmental sciences is now allowing for more …

[BUCH][B] Affect dysregulation and disorders of the self (Norton Series on Interpersonal Neurobiology)

A Schore - 2003 - books.google.com
This volume (one of two) is the first presentation of Schore's comprehensive theory in book
form, as it has developed since 1994. In 1994 Allan Schore published his groundbreaking …

Memory modulation.

B Roozendaal, JL McGaugh - Behavioral neuroscience, 2011 - psycnet.apa.org
Our memories are not all created equally strong: Some experiences are well remembered
while others are remembered poorly, if at all. Research on memory modulation investigates …