Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Prescribing the frequency, duration, or volume of training is simple as these factors can be
altered by manipulating the number of exercise sessions per week, the duration of each …

Engaging in regular exercise results in a range of physiological adaptations offering benefits
for exercise capacity and health, independent of age, gender or the presence of chronic …

New Findings What is the topic of this review? We review sex differences within
physiological systems implicated in exercise performance; specifically, how they integrate to …

Physical exercise is of great significance for maintaining human health. Exercise can
provide varying degrees of benefits to cognitive function at all stages of life cycle. Currently …

Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely
interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory …

Regular exercise is associated with pronounced health benefits. The molecular processes
involved in physiological adaptations to exercise are best understood in skeletal muscle …

Ageing is associated with widespread physiological changes prominent within all tissues,
including skeletal muscle and the brain, which lead to a decline in physical function. To …

Analyses of mitochondrial adaptations in human skeletal muscle have mostly used whole-
muscle samples, where results may be confounded by the presence of a mixture of type I …

Mitochondrial defects are implicated in multiple diseases and aging. Exercise training is an
accessible, inexpensive therapeutic intervention that can improve mitochondrial …