The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - Elsevier
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Cadmium and its neurotoxic effects

B Wang, Y Du - Oxidative medicine and cellular longevity, 2013 - Wiley Online Library
Cadmium (Cd) is a heavy metal that has received considerable concern environmentally
and occupationally. Cd has a long biological half‐life mainly due to its low rate of excretion …

Molecular physiology of low-voltage-activated t-type calcium channels

E Perez-Reyes - Physiological reviews, 2003 - journals.physiology.org
T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because
they can be activated by small depolarizations of the plasma membrane. In many neurons …

Central and peripheral contributions of T-type calcium channels in pain

EK Harding, GW Zamponi - Molecular brain, 2022 - Springer
Chronic pain is a severely debilitating condition that reflects a long-term sensitization of
signal transduction in the afferent pain pathway. Among the key players in this pathway are …

[HTML][HTML] Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

S Heyes, WS Pratt, E Rees, S Dahimene, L Ferron… - Progress in …, 2015 - Elsevier
This review summarises genetic studies in which calcium channel genes have been
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …

Multiple types of neuronal calcium channels and their selective modulation

RW Tsien, D Lipscombe, DV Madison, KR Bley… - Trends in …, 1988 - cell.com
Voltage-gated Ca e+ channels control the entry of Ca e+ ions across the surface membrane
of neurons and other cells and thereby influence electrical activity and diverse cellular …

Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells

TF McDonald, S Pelzer, W Trautwein… - Physiological …, 1994 - journals.physiology.org
I. OVERVIEW AND NOMENCLATURE Times change. In 1926, the writer of a review in this
journal noted that over 350 papers had appeared on the subject during the previous 2 years …

Traumatic optic neuropathy

KD Steinsapir, RA Goldberg - Survey of ophthalmology, 1994 - Elsevier
Abstract Knowledge concerning the pathophysiologic mechanisms of traumatic optic
neuropathy is limited. The optic nerve is a tract of the brain. Therefore, the cellular and …

P-type calcium channels blocked by the spider toxin ω-Aga-IVA

IM Mintz, VJ Venema, KM Swiderek, TD Lee, BP Bean… - Nature, 1992 - nature.com
VOLTAGE-DEPENDENT calcium channels mediate calcium entry into neurons, which is
crucial for many processes in the brain including synaptic transmission, dendritic spiking …

Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells

SHR Oliet, RC Malenka, RA Nicoll - Neuron, 1997 - cell.com
Two distinct forms of long-term depression (LTD), one dependent on the activation of NMDA
receptors (NMDARs) and the other dependent on the activation of metabotropic glutamate …