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The IL-17 family in diseases: from bench to bedside
L Huangfu, R Li, Y Huang, S Wang - Signal transduction and targeted …, 2023 - nature.com
Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …
recently, all of its related receptors have been discovered. IL-17 was first discovered …
IL-17 and IL-17-producing cells in protection versus pathology
IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …
immunity against many pathogens but also driving inflammatory pathology during infection …
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …
Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders
The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …
The end of AIDS: HIV infection as a chronic disease
The success of antiretroviral therapy has led some people to now ask whether the end of
AIDS is possible. For patients who are motivated to take therapy and who have access to …
AIDS is possible. For patients who are motivated to take therapy and who have access to …
Oxidative stress during HIV infection: mechanisms and consequences
It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …
Systemic effects of inflammation on health during chronic HIV infection
Combination antiretroviral therapy for HIV infection improves immune function and
eliminates the risk of AIDS-related complications but does not restore full health. HIV …
eliminates the risk of AIDS-related complications but does not restore full health. HIV …
HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased …
A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity
and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) …
and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) …
Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa
Mammals co-exist with resident microbial ecosystem that is composed of an incredible
number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident …
number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident …
Indoleamine 2, 3 dioxygenase and metabolic control of immune responses
Sustained access to nutrients is a fundamental biological need, especially for proliferating
cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to …
cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to …