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Multicomponent reactions (MCR) in medicinal chemistry: a patent review (2010-2020)
HA Younus, M Al-Rashida, A Hameed… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Multicomponent reactions (MCR) has been utilized to synthesize a vast range
of analogs belonging to diverse classes of heterocyclic compounds offering …
of analogs belonging to diverse classes of heterocyclic compounds offering …
[HTML][HTML] Multicomponent reactions for the synthesis of active pharmaceutical ingredients
Á Cores, J Clerigué, E Orocio-Rodríguez… - Pharmaceuticals, 2022 - mdpi.com
Multicomponent reactions 9i. e., those that engage three or more starting materials to form a
product that contains significant fragments of all of them), have been widely employed in the …
product that contains significant fragments of all of them), have been widely employed in the …
A Phosphine-Free Air-Stable Mn(II)-Catalyst for Sustainable Synthesis of Quinazolin-4(3H)-ones, Quinolines, and Quinoxalines in Water
The synthesis, characterization, and catalytic application of a new phosphine-free, well-
defined, water-soluble, and air-stable Mn (II)-catalyst [Mn (L)(H2O) 2Cl](Cl)([1] Cl) featuring a …
defined, water-soluble, and air-stable Mn (II)-catalyst [Mn (L)(H2O) 2Cl](Cl)([1] Cl) featuring a …
A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …
S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …
They are widely used in a variety of pharmacological and industrial applications. Their …
Visible-light-mediated three-Component strategy for the synthesis of isoxazolines and isoxazoles
Y Li, Y Zhang, J Wang, D **a, M Zhuo, L Zhu, D Li… - Organic …, 2024 - ACS Publications
Isoxazolines and isoxazoles commonly serve as core structures of many therapeutic agents
and natural products. However, the metal-free and catalysis-free strategy for the synthesis of …
and natural products. However, the metal-free and catalysis-free strategy for the synthesis of …
Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives
D He, M Wang, S Zhao, Y Shu, H Zeng, C **ao, C Lu… - Fitoterapia, 2017 - Elsevier
Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted
increasing interest because of their broad spectrum of biological functions. This review …
increasing interest because of their broad spectrum of biological functions. This review …
Green synthesis of novel pyridines via one-pot multicomponent reaction and their anti-inflammatory evaluation
A functional and environmentally green procedure for the design of novel pyridine 5a–h and
7a–d derivatives through two pathways is presented. The first pathway is via a one-pot, four …
7a–d derivatives through two pathways is presented. The first pathway is via a one-pot, four …
One-Pot Three-Component Reaction for the Synthesis of 3,4-Dihydroquinazolines and Quinazolin-4(3H)-ones
S Chen, YS Ji, Y Choi, SW Youn - The Journal of Organic …, 2024 - ACS Publications
A highly efficient and straightforward one-pot synthesis of diversely substituted 3, 4-
dihydroquinazolines and quinazolin-4 (3 H)-ones has been achieved through a domino …
dihydroquinazolines and quinazolin-4 (3 H)-ones has been achieved through a domino …
Synthesis of 1, 2, 3-triazole linked 4 (3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus
Methicillin and vancomycin resistant Staphylococcus aureus infections are an emerging
global health concern leading to increasing morbidity and mortality. Continuous increase in …
global health concern leading to increasing morbidity and mortality. Continuous increase in …
Visible light-mediated synthesis of quinazolinones and benzothiadiazine-1, 1-dioxides utilizing aliphatic alcohols
The activation and utilization of challenging aliphatic alcohols like methanol and ethanol is a
very appealing approach to synthesize valuable organic molecules. Utilization of methanol …
very appealing approach to synthesize valuable organic molecules. Utilization of methanol …