Polyunsaturated fatty acids and their metabolites in brain function and disease

RP Bazinet, S Layé - Nature reviews neuroscience, 2014‏ - nature.com
The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids
(PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the …

[PDF][PDF] RETRACTED ARTICLE: Functional behavior of DHA and EPA in the formation of babies brain at different stages of age, and protect from different brain-related …

W Khalid, P Gill, MS Arshad, A Ali… - … Journal of Food …, 2022‏ - Taylor & Francis
Statement of Retraction We, the Editors and Publisher of the journal International Journal of
Food Properties, have retracted the following articles: Waseem Khalid, Poonam Gill …

N-3 polyunsaturated fatty acids in animal models with neuroinflammation: an update

MO Trépanier, KE Hopperton, SK Orr… - European journal of …, 2016‏ - Elsevier
Neuroinflammation is a characteristic of a multitude of neurological and psychiatric
disorders. Modulating inflammatory pathways offers a potential therapeutic target in these …

n-3 Polyunsaturated fatty acids in animal models with neuroinflammation

SK Orr, MO Trépanier, RP Bazinet - Prostaglandins, Leukotrienes and …, 2013‏ - Elsevier
Neuroinflammation is present in the majority of acute and chronic neurological disorders.
Excess or prolonged inflammation in the brain is thought to exacerbate neuronal damage …

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

M Hennebelle, Z Zhang, AH Metherel, AP Kitson… - Scientific reports, 2017‏ - nature.com
Abstract Linoleic acid (LA; 18: 2 n-6), the most abundant polyunsaturated fatty acid in the US
diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we …

Localized delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat brain using focused ultrasound

RS Mulik, C Bing, M Ladouceur-Wodzak, I Munaweera… - Biomaterials, 2016‏ - Elsevier
Focused ultrasound exposures in the presence of microbubbles can achieve transient, non-
invasive, and localized blood–brain barrier (BBB) opening, offering a method for targeted …

Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study

CM DeGiorgio, PR Miller, R Harper… - Journal of Neurology …, 2015‏ - jnnp.bmj.com
Background n-3 fatty acids inhibit neuronal excitability and reduce seizures in animal
models. High-dose fish oil has been explored in two randomised trials in drug resistant …

Retinoid X receptor α regulates DHA-dependent spinogenesis and functional synapse formation in vivo

H Cao, MY Li, G Li, SJ Li, B Wen, Y Lu, X Yu - Cell Reports, 2020‏ - cell.com
Coordinated intracellular and extracellular signaling is critical to synapse development and
functional neural circuit wiring. Here, we report that unesterified docosahexaenoic acid …

[HTML][HTML] Functional nutrients for epilepsy

JE Kim, KO Cho - Nutrients, 2019‏ - mdpi.com
Epilepsy is a common neurological disorder of which seizures are a core symptom.
Approximately one third of epileptic patients are resistant to antiepileptic drugs and therefore …

Omega-3 fatty acids (ῳ-3 fatty acids) in epilepsy: animal models and human clinical trials

CM DeGiorgio, AY Taha - Expert review of neurotherapeutics, 2016‏ - Taylor & Francis
Introduction: There is growing interest in alternative and nutritional therapies for drug
resistant epilepsy. ῳ-3 fatty acids such as fish or krill oil are widely available supplements …