Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities
X Jiang, K Wu, R Bai, P Zhang, Y Zhang - European Journal of Medicinal …, 2022 - Elsevier
Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …
Designing strategies, structural activity relationship and biological activity of recently developed nitrogen containing heterocyclic compounds as epidermal growth …
Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …
unchecked production of definite molecules. These molecules are involved in the cell growth …
Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm …
Nowadays, it's imperative to develop novel antimicrobial agents active against both drug-
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …
Anticancer effects with molecular docking confirmation of newly synthesized isatin sulfonamide molecular hybrid derivatives against hepatic cancer cell lines
The current study investigated the cytotoxic effect of ten sulfonamide-derived isatins,
following molecular hybridization, based on the association principles, on hepatocellular …
following molecular hybridization, based on the association principles, on hepatocellular …
Synthesis, characterization, thermal properties, antimicrobial evaluation, ADMET study, and molecular docking simulation of new mono Cu (II) and Zn (II) complexes …
One of the interesting research fields is develo** and assessing novel metal-containing
medications. A new isatin-3-thiosemicarbazone derivative 4 was synthesized by two …
medications. A new isatin-3-thiosemicarbazone derivative 4 was synthesized by two …
Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study
KE Saadon, NMH Taha, NA Mahmoud… - Journal of the Iranian …, 2022 - Springer
A new series of pyridine-2-one and pyrazole derivatives were designed and synthesized
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …
Evaluation of the anti-proliferative activity of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives as a new class of EGFR Wt and VEGFR-2 inhibitors with apoptotic …
RR Raslan, YA Ammar, SA Fouad, SA Hessein… - RSC …, 2023 - pubs.rsc.org
Develo** new agents for cancer treatment remains a top priority because it is one of the
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
A novel of quinoxaline derivatives tagged with pyrrolidinyl scaffold as a new class of antimicrobial agents: Design, synthesis, antimicrobial activity, and molecular …
MM Abdelgalil, YA Ammar, GAME Ali, AK Ali… - Journal of Molecular …, 2023 - Elsevier
Globally, infectious diseases are becoming harder to treat due to antibiotic resistance, which
has reached high levels. Additionally, develo** new therapeutic options to combat the …
has reached high levels. Additionally, develo** new therapeutic options to combat the …
One-pot synthesis and molecular modeling studies of new bioactive spiro-oxindoles based on uracil derivatives as SARS-CoV-2 inhibitors targeting RNA polymerase …
The first outbreak in Wuhan, China, in December 2019 was reported about severe acute
coronaviral syndrome 2 (SARS-CoV-2). The global coronavirus disease 2019 (COVID-19) …
coronaviral syndrome 2 (SARS-CoV-2). The global coronavirus disease 2019 (COVID-19) …
A new class of anti-proliferative activity and apoptotic inducer with molecular docking studies for a novel of 1, 3-dithiolo [4, 5-b] quinoxaline derivatives hybrid with a …
A new series of 6-(pyrrolidin-1-ylsulfonyl)-[1, 3] dithiolo [4, 5-b] quinoxaline-2-ylidines 10a–f,
12, 14, 16, and 18 were designed, synthesized, and evaluated for their in vitro anticancer …
12, 14, 16, and 18 were designed, synthesized, and evaluated for their in vitro anticancer …