Molecular actions of glucocorticoids in cartilage and bone during health, disease, and steroid therapy

K Hartmann, M Koenen, S Schauer… - Physiological …, 2016 - journals.physiology.org
Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that
are frequently used to treat inflammatory diseases. Major complications associated with long …

Stromal fibroblasts in tertiary lymphoid structures: a novel target in chronic inflammation

F Barone, DH Gardner, S Nayar, N Steinthal… - Frontiers in …, 2016 - frontiersin.org
Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid, and
stromal cells that provide ectopic hubs for acquired immune responses. TLS share …

Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling

C Miao, Y Yang, X He, X Li, C Huang, Y Huang… - Cellular signalling, 2013 - Elsevier
Rheumatoid arthritis (RA) is a chronic symmetrical autoimmune disease of unknown etiology
that affects primarily the diarthrodial joints. Characteristic features of RA pathogenesis are …

Arthritis and the role of endogenous glucocorticoids

E Macfarlane, MJ Seibel, H Zhou - Bone research, 2020 - nature.com
Rheumatoid arthritis and osteoarthritis, the most common forms of arthritis, are chronic,
painful, and disabling conditions. Although both diseases differ in etiology, they manifest in …

Involvement of the Wnt‐β‐catenin signalling antagonists, sclerostin and dickkopf‐related protein 1, in chronic periodontitis

MH Napimoga, C Nametala, FL da Silva… - Journal of clinical …, 2014 - Wiley Online Library
Abstract Aim The regulation of Wnt‐β‐catenin signalling, which is crucial for osteoblast
differentiation and for bone resorption, is driven by critical inhibitors such as sclerostin …

MiR-613 inhibits proliferation and invasion and induces apoptosis of rheumatoid arthritis synovial fibroblasts by direct down-regulation of DKK1

L Liu, Y Zuo, Y Xu, Z Zhang, Y Li, J Pang - Cellular & molecular biology …, 2019 - Springer
Background This study aimed to investigate the effects of miR-613 on the proliferation,
invasion and apoptosis of rheumatoid arthritis synovial fibroblasts (RASFs). Methods …

Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical wnt signaling

Y Yuan, MK Call, Y Yuan, Y Zhang… - … & visual science, 2013 - iovs.arvojournals.org
Purpose.: Dexamethasone (DEX) regulates aqueous humor outflow by inducing a
reorganization of the cytoskeleton to form cross-linked actin networks (CLANs) in trabecular …

A machine learning heuristic to identify biologically relevant and minimal biomarker panels from omics data

AL Swan, DJ Stekel, C Hodgman, D Allaway… - BMC genomics, 2015 - Springer
Background Investigations into novel biomarkers using omics techniques generate large
amounts of data. Due to their size and numbers of attributes, these data are suitable for …

Activation of dickkopf-1 and focal adhesion kinase pathway by tumour necrosis factor α induces enhanced migration of fibroblast-like synoviocytes in rheumatoid …

JY Choe, J Hun Kim, KY Park, CH Choi… - Rheumatology, 2016 - academic.oup.com
Objective. The objective of this study was to investigate the roles of dickkopf-1 (DKK-1) and
integrin-related focal adhesion kinase (FAK) by TNF-α on the migration of fibroblast-like …

Metabolomic analysis in spondyloarthritis: A systematic review

T Huang, Y Pu, X Wang, Y Li, H Yang, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Spondyloarthritis (SpA) is a group of rheumatic diseases that cause joint inflammation.
Accumulating studies have focused on the metabolomic profiling of SpA in recent years. We …