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Molecular actions of glucocorticoids in cartilage and bone during health, disease, and steroid therapy
K Hartmann, M Koenen, S Schauer… - Physiological …, 2016 - journals.physiology.org
Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that
are frequently used to treat inflammatory diseases. Major complications associated with long …
are frequently used to treat inflammatory diseases. Major complications associated with long …
Stromal fibroblasts in tertiary lymphoid structures: a novel target in chronic inflammation
Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid, and
stromal cells that provide ectopic hubs for acquired immune responses. TLS share …
stromal cells that provide ectopic hubs for acquired immune responses. TLS share …
Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling
C Miao, Y Yang, X He, X Li, C Huang, Y Huang… - Cellular signalling, 2013 - Elsevier
Rheumatoid arthritis (RA) is a chronic symmetrical autoimmune disease of unknown etiology
that affects primarily the diarthrodial joints. Characteristic features of RA pathogenesis are …
that affects primarily the diarthrodial joints. Characteristic features of RA pathogenesis are …
Arthritis and the role of endogenous glucocorticoids
Rheumatoid arthritis and osteoarthritis, the most common forms of arthritis, are chronic,
painful, and disabling conditions. Although both diseases differ in etiology, they manifest in …
painful, and disabling conditions. Although both diseases differ in etiology, they manifest in …
Involvement of the Wnt‐β‐catenin signalling antagonists, sclerostin and dickkopf‐related protein 1, in chronic periodontitis
MH Napimoga, C Nametala, FL da Silva… - Journal of clinical …, 2014 - Wiley Online Library
Abstract Aim The regulation of Wnt‐β‐catenin signalling, which is crucial for osteoblast
differentiation and for bone resorption, is driven by critical inhibitors such as sclerostin …
differentiation and for bone resorption, is driven by critical inhibitors such as sclerostin …
MiR-613 inhibits proliferation and invasion and induces apoptosis of rheumatoid arthritis synovial fibroblasts by direct down-regulation of DKK1
L Liu, Y Zuo, Y Xu, Z Zhang, Y Li, J Pang - Cellular & molecular biology …, 2019 - Springer
Background This study aimed to investigate the effects of miR-613 on the proliferation,
invasion and apoptosis of rheumatoid arthritis synovial fibroblasts (RASFs). Methods …
invasion and apoptosis of rheumatoid arthritis synovial fibroblasts (RASFs). Methods …
Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical wnt signaling
Y Yuan, MK Call, Y Yuan, Y Zhang… - … & visual science, 2013 - iovs.arvojournals.org
Purpose.: Dexamethasone (DEX) regulates aqueous humor outflow by inducing a
reorganization of the cytoskeleton to form cross-linked actin networks (CLANs) in trabecular …
reorganization of the cytoskeleton to form cross-linked actin networks (CLANs) in trabecular …
A machine learning heuristic to identify biologically relevant and minimal biomarker panels from omics data
Background Investigations into novel biomarkers using omics techniques generate large
amounts of data. Due to their size and numbers of attributes, these data are suitable for …
amounts of data. Due to their size and numbers of attributes, these data are suitable for …
Activation of dickkopf-1 and focal adhesion kinase pathway by tumour necrosis factor α induces enhanced migration of fibroblast-like synoviocytes in rheumatoid …
JY Choe, J Hun Kim, KY Park, CH Choi… - Rheumatology, 2016 - academic.oup.com
Objective. The objective of this study was to investigate the roles of dickkopf-1 (DKK-1) and
integrin-related focal adhesion kinase (FAK) by TNF-α on the migration of fibroblast-like …
integrin-related focal adhesion kinase (FAK) by TNF-α on the migration of fibroblast-like …
Metabolomic analysis in spondyloarthritis: A systematic review
T Huang, Y Pu, X Wang, Y Li, H Yang, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Spondyloarthritis (SpA) is a group of rheumatic diseases that cause joint inflammation.
Accumulating studies have focused on the metabolomic profiling of SpA in recent years. We …
Accumulating studies have focused on the metabolomic profiling of SpA in recent years. We …