The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

The solution and complexation chemistry of zinc ions is the basis for zinc biology. In living
organisms, zinc is redox-inert and has only one valence state: Zn (II). Its coordination …

Around 3000 proteins are thought to bind zinc in vivo, which corresponds to~ 10% of the
human proteome. Zinc plays a pivotal role as a structural, catalytic, and signaling component …

The nutritional essentiality of zinc for the growth of living organisms had been recognized
long before zinc biochemistry began with the discovery of zinc in carbonic anhydrase in …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Zinc and cellular oxidants such as reactive oxygen species (ROS) each participate in a
multitude of physiological functions. There is considerable overlap between the affected …

Recent discoveries in zinc biology provide a new platform for discussing the primary
physiological functions of mammalian metallothioneins (MTs) and their exquisite zinc …

Higher eukaryotes' life is impossible without copper redox activity and, literally, every breath
we take biochemically demonstrates this. However, this dependence comes at a …

Zinc (II) ions are redox-inert in biology. Yet, their interaction with sulfur of cysteine in cellular
proteins can confer ligand-centered redox activity on zinc coordination sites, control protein …