The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …

The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

Emotional states influence bodily physiology, as exemplified in the top-down process by
which anxiety causes faster beating of the heart,–. However, whether an increased heart …

Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain
activity. However, the whole-brain organization of PFC axon projections remains poorly …

Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …

Social behaviors are crucial to all mammals. Although the prelimbic cortex (PL, part of
medial prefrontal cortex) has been implicated in social behavior, it is not clear which …

Learning to predict threat is essential, but equally important—yet often overlooked—is
learning about the absence of threat. Here, by recording neural activity in two nucleus …

The ability of the taste system to identify a tastant (what it tastes like) enables animals to
recognize and discriminate between the different basic taste qualities,. The valence of a …

Dysfunction of the mesocorticolimbic dopaminergic reward system is a core feature of
schizophrenia (SZ), yet its precise contributions to different stages of reward processing and …

In motor neuroscience, state changes are hypothesized to time-lock neural assemblies
coordinating complex movements, but evidence for this remains slender. We tested whether …