A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle

AJ Zmuda, X Kang, KB Wissbroecker… - Nature …, 2024 - nature.com
A prevalent side-reaction of succinate dehydrogenase oxidizes malate to enol-oxaloacetate
(OAA), a metabolically inactive form of OAA that is a strong inhibitor of succinate …

Oxaloacetate mediates mitochondrial metabolism and function

L Yu, WI Sivitz - Current Metabolomics and Systems Biology …, 2020 - ingentaconnect.com
Oxaloacetate, an intermediate in the tricarboxylic acid cycle, plays important roles in
regulating mitochondrial function, gluconeogenesis, the urea cycle, and amino acid …

Decanoic acid and not octanoic acid stimulates fatty acid synthesis in U87MG glioblastoma cells: a metabolomics study

F Damiano, GE De Benedetto, S Longo… - Frontiers in …, 2020 - frontiersin.org
Medium-chain fatty acids (MCFA) are dietary components with a chain length ranging from 6
to 12 carbon atoms. MCFA can cross the blood-brain barrier and in the brain can be …

[HTML][HTML] Regulation of cellular senescence by eukaryotic members of the FAH superfamily–A role in calcium homeostasis?

AKH Weiss, E Albertini, M Holzknecht… - Mechanisms of ageing …, 2020 - Elsevier
Fumarylacetoacetate hydrolase (FAH) superfamily members are commonly expressed in the
prokaryotic kingdom, where they take part in the committing steps of degradation pathways …

AtFAHD1a: a new player influencing seed longevity and dormancy in Arabidopsis?

D Gerna, E Arc, M Holzknecht, T Roach… - International Journal of …, 2021 - mdpi.com
Fumarylacetoacetate hydrolase (FAH) proteins form a superfamily found in Archaea,
Bacteria, and Eukaryota. However, few fumarylacetoacetate hydrolase domain (FAHD) …

Mitochondrial enzyme FAHD1 reduces ROS in osteosarcoma

A Heberle, E Cappuccio, A Andric, T Kuen… - Scientific Reports, 2024 - nature.com
This study investigated the impact of overexpressing the mitochondrial enzyme
Fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) in human …

Structural and Functional Characterization of a Novel Class A Flavin Monooxygenase from Bacillus niacini

BC Richardson, ZR Turlington… - Biochemistry, 2024 - ACS Publications
A gene cluster responsible for the degradation of nicotinic acid (NA) in Bacillus niacini has
recently been identified, and the structures and functions of the resulting enzymes are …

Metal-catalyzed decarboxylation of oxaloacetic acid studied in silico and in vitro, implications for enzymatic and prebiotic catalysis

O Yañez, R Cabrera, R Pino-Rios, C Sepúlveda… - Journal of Molecular …, 2025 - Elsevier
During the decarboxylation of oxaloacetic acid (OAA), an α-keto acid that participates in the
central metabolic pathways of all organisms, its fourth carbon is released in the form of CO 2 …

Crystal Structure of l-2,4-Diketo-3-deoxyrhamnonate Hydrolase Involved in the Nonphosphorylated l-Rhamnose Pathway from Bacteria

S Fukuhara, S Watanabe, Y Watanabe… - Biochemistry, 2022 - ACS Publications
2, 4-Diketo-3-deoxy-l-rhamnonate (L-DKDR) hydrolase (LRA6) catalyzes the hydrolysis
reaction of L-DKDR to pyruvate and l-lactate in the nonphosphorylated l-rhamnose pathway …

Erythropoietin regulates transcription and YY1 dynamics in a pre-established chromatin architecture

AA Perreault, JD Brown, BJ Venters - Iscience, 2020 - cell.com
The three-dimensional architecture of the genome plays an essential role in establishing
and maintaining cell identity. However, the magnitude and temporal kinetics of changes in …