Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …

Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

The coagulase-negative bacterium Staphylococcus epidermidis is a member of the human
skin microbiota. S. epidermidis is not merely a passive resident on skin but actively primes …

Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …

Drug combinations are widely used in clinical practice to prevent the evolution of resistance.
However, little is known about the effect of tolerance, a different mode of survival, on the …

Emerging antibiotic resistant bacteria constitute one of the biggest threats to public health.
Surface-enhanced Raman scattering (SERS) is highly promising for detecting such bacteria …

Coagulase-negative staphylococci (CoNS) have emerged as major pathogens in healthcare-
associated facilities, being S. epidermidis, S. haemolyticus and, more recently, S …

Antibiotic resistance is a relevant topic nowadays, representing one of the main causes of
infection-related mortality and morbidity at a global level. This phenomenon is worrisome …

Pathogenic biofilms are up to 1000-fold more drug-resistant than planktonic pathogens and
cause about 80% of all chronic infections worldwide. The lack of prompt and reliable biofilm …

Staphylococcus aureus causes invasive infections and easily acquires antibiotic resistance.
Even antibiotic-susceptible S. aureus can survive antibiotic therapy and persist, requiring …