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Role of bromodomain and extraterminal (BET) proteins in prostate cancer
A Mandl, MC Markowski, MA Carducci… - Expert opinion on …, 2023 - Taylor & Francis
Introduction The bromodomain and extraterminal (BET) family of proteins are epigenetic
readers of acetylated histones and are critical activators of oncogenic networks across many …
readers of acetylated histones and are critical activators of oncogenic networks across many …
RB functions as a key regulator of senescence and tumor suppression
M Gao, H Li, J Zhang - Seminars in Cancer Biology, 2024 - Elsevier
The Retinoblastoma (RB) protein is crucial for regulating gene transcription and chromatin
remodeling, impacting cell cycle progression, cellular senescence, and tumorigenesis …
remodeling, impacting cell cycle progression, cellular senescence, and tumorigenesis …
The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
M Feng, H Xu, W Zhou, Y Pan - Journal of Experimental & Clinical Cancer …, 2023 - Springer
Background Advanced gastric cancer (GC) is a lethal malignancy, harboring recurrent
alterations in cell cycle pathway, especially the CDKN2A-CDK4/CDK6/CCND1 axis …
alterations in cell cycle pathway, especially the CDKN2A-CDK4/CDK6/CCND1 axis …
Co‐targeting BET, CBP, and p300 inhibits neuroendocrine signalling in androgen receptor‐null prostate cancer
There are diverse phenotypes of castration‐resistant prostate cancer, including
neuroendocrine disease, that vary in their sensitivity to drug treatment. The efficacy of BET …
neuroendocrine disease, that vary in their sensitivity to drug treatment. The efficacy of BET …
[HTML][HTML] Pyronaridine as a Bromodomain-Containing Protein 4-N-Terminal Bromodomain (BRD4-BD1) Inhibitor: In Silico Database Mining, Molecular Docking, and …
BRD4 (bromodomain-containing protein 4) is an epigenetic reader that realizes histone
proteins and promotes the transcription of genes linked to cancer progression and non …
proteins and promotes the transcription of genes linked to cancer progression and non …
Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis
Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate
cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 …
cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 …
BRD4 promotes immune escape of glioma cells by upregulating PD-L1 expression
Y Liu, L Cai, H Wang, L Yao, Y Wu, K Zhang… - Journal of Neuro …, 2024 - Springer
Purpose Glioblastoma multiforme (GBM) poses significant challenges in treatment due to its
aggressive nature and immune escape mechanisms. Despite recent advances in immune …
aggressive nature and immune escape mechanisms. Despite recent advances in immune …
[HTML][HTML] Effective therapeutic targeting of tumor lineage plasticity in neuroendocrine prostate cancer by BRD4 inhibitors
Tumor lineage plasticity (LP) is an emerging hallmark of cancer progression. Through
pharmacologically probing the function of epigenetic regulators in prostate cancer cells and …
pharmacologically probing the function of epigenetic regulators in prostate cancer cells and …
[HTML][HTML] Unlocking the therapeutic potential of selective CDK7 and BRD4 Inhibition against multiple myeloma cell growth
Y Yao, S Deng, JF Ng, M Yuan, C Chakraborty… - …, 2024 - pmc.ncbi.nlm.nih.gov
Multiple myeloma (MM) is a plasma cell malignancy that is considered incurable despite the
recent therapeutic advances. Effective targeted therapies are, therefore, needed. Our …
recent therapeutic advances. Effective targeted therapies are, therefore, needed. Our …
Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response
Integrated human papillomavirus (HPV-16) associated head and neck squamous cell
carcinoma (HNSCC) tumors have worse survival outcomes compared to episomal HPV-16 …
carcinoma (HNSCC) tumors have worse survival outcomes compared to episomal HPV-16 …