New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called
apicoplast that is the most reduced organelle of this type known. Due to the medical …

Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to
its prokaryotic origin and essential function, the apicoplast is a key target for development of …

Heme is an essential cofactor for aerobic organisms. Its redox chemistry is central to a
variety of biological functions mediated by hemoproteins. In blood stages, malaria parasites …

Heme metabolism is central to malaria parasite biology. The parasite acquires heme from
host hemoglobin in the intraerythrocytic stages and stores it as hemozoin to prevent free …

Genome‐scale metabolic reconstructions can serve as important tools for hypothesis
generation and high‐throughput data integration. Here, we present a metabolic network …

All eight enzymes required for de novo heme biosynthesis have been predicted from the
nuclear genome of the human malaria parasite Plasmodium falciparum. We have studied …

Heme-biosynthetic pathway of malaria parasite is dispensable for asexual stages, but
essential for mosquito and liver stages. Despite having backup mechanisms to acquire …

Iron deficiency affects one quarter of the world's population and causes significant morbidity,
including detrimental effects on immune function and cognitive development. Accordingly …

Significance: Heme is an essential prosthetic group for most life on Earth. It functions in
numerous cellular redox reactions, including in antioxidant defenses and at several stages …