The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …

The nucleophosmin (NPM1) gene encodes for a multifunctional chaperone protein that is
localized in the nucleolus but continuously shuttles between the nucleus and cytoplasm …

The aim of this literature review is to examine the significance of the nucleophosmin 1
(NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure …

Abstract Glycogen synthase kinase 3 (GSK-3) consists of two isoforms (α and β) that were
originally linked to glucose metabolism regulation. However, GSK-3 is also involved in …

The nucleophosmin (NPM1) gene encodes for the most abundant nucleolar protein. Thanks
to its property to act as histone chaperone and to shuttle between the nucleus and …

Acute myeloid leukemia (AML) with a nucleophosmin 1 (NPM1) mutation is a unique
subtype of adult leukemia. Recent studies show that NPM1-mutated AML has high …

ABSTRACT Mutations in nucleophosmin 1 (NPM1) are diseased‐defining genetic
alterations encountered in approximately one‐third of cases of acute myeloid leukemia …

Acute myeloid leukemia (AML) is a heterogeneous group of diseases classified into various
types on the basis of distinct features concerning the morphology, cytochemistry and …

Many transcription factors (TFs) function as tumor suppressor genes with heterozygous
phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia …

Additional supporting information may be found online in the Supporting Information section
at the end of the article. Figure S1. Age-specific incidence rates of patients with chronic …