Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …

Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …

SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …

The organization of the genome in the nucleus and the interactions of genes with their
regulatory elements are key features of transcriptional control and their disruption can cause …

Proper expression of genes requires communication with their regulatory elements that can
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …

Mammalian genes transcribe RNA not continuously, but in bursts. Transcriptional output can
be modulated by altering burst fraction or burst size, but how regulatory elements control …

Abstract We present Micro-C XL, an improved method for analysis of chromosome folding at
mononucleosome resolution. Using long crosslinkers and isolation of insoluble chromatin …

Background The relationship between transcription and the 3D chromatin structure is
debated. Multiple studies have shown that transcription affects global Cohesin binding and …

Gene transcription by RNA polymerase II (Pol II) is under control of promoters and distal
regulatory elements known as enhancers. Enhancers are themselves transcribed by Pol II …