Partial least squares (PLS) is an efficient statistical regression technique that is highly suited
for the analysis of genomic and proteomic data. In this article, we review both the theory …

Metabolomics is the study of metabolism at the global level. This rapidly develo** new
discipline has important potential implications for pharmacologic science. The concept that …

Metabolomics is the global analysis of all or a large number of cellular metabolites. Like
other functional genomics research, metabolomics generates large amounts of data …

Background: Glycosylated proteins play important roles in cell-to-cell interactions,
immunosurveillance, and a variety of receptor-mediated and specific protein functions …

This review, the seventeenth of this series and the fifteenth with the title of Chemometrics,
covers the most significant developments in the field from January 2006 through December …

Glycomic profiles derived from human blood sera of 10 healthy males were compared to
those from 24 prostate cancer patients. The profiles were acquired using MALDI− MS of …

Acid ceramidase (N-acylsphingosine deacylase, EC 3.5. 1.23; AC) is the lipid hydrolase
responsible for the degradation of ceramide into sphingosine and free fatty acids within …

Ceramide, the backbone structure of all sphingolipids, as well as a minor component of
cellular membranes, has a unique role in the skin, by forming the epidermal permeability …

It is well known that significant metabolic change take place as cells are transformed from
normal to malignant. This review focuses on the use of different bioinformatics tools in …

Multivariate partial least square (PLS) regression allows the modeling of complex biological
events, by considering different factors at the same time. It is unaffected by data collinearity …