Challenges in quantifying how force affects bond formation have hindered the widespread
adoption of mechanochemistry. We used parallel tip-based methods to determine reaction …

Computational organic chemistry has become a valuable tool in the field of bioorthogonal
chemistry, offering insights and aiding in the progression of this branch of chemistry. In this …

The enantioselective Povarov reaction is one of the most powerful synthetic strategy to
synthesize chiral, highly functionalized 1, 2, 3, 4‐tetrahydroquinolines. The present …

Monosubstituted tetrazines are important bioorthogonal reactive tools due to their rapid
ligation with trans-cyclooctene. However, their application is limited by the reactivity–stability …

We report that the dearomative [4+ 2] cycloaddition between 1, 2-dihydro-1, 2, 4, 5-tetrazine-
3, 6-diones (TETRADs) and benzenes, naphthalenes, or N-heteroaromatic compounds …

Chiral pyrazolones with a spirocyclic centre at the C4-position are widely found in a large
family of medically relevant compounds. In recent years, organocatalysis, particularly that …

Abstract 1, 2, 4, 5‐Tetrazines are increasingly used as reactants in bioorthogonal chemistry
due to their high reactivity in Diels–Alder reactions with various dienophiles. Substituents in …

A regioselective synthesis of trisubstituted pyridazines from tetrazines and alkynyl sulfides is
described. Various pyridazines were selectively prepared by the inverse-electron-demand …

Herein, we report the synthesis and characterization of a series of thioarylmaleimides and
their varied propensity toward highly selective domino Diels–Alder (D–A)/rearrangement, D …

Computational analyses have revealed that the distortion of a catalyst and the substrates
and their interactions are key to determining the stability of the transition state. Hence, two …