Merging microfluidics with luminescence immunoassays for urgent point-of-care diagnostics of COVID-19

H Yuan, P Chen, C Wan, Y Li, BF Liu - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Abstract The Coronavirus disease 2019 (COVID-19) outbreak has urged the establishment
of a global-wide rapid diagnostic system. Current widely-used tests for COVID-19 include …

Recent progress in nucleic acid detection with CRISPR

FX Liu, JQ Cui, Z Wu, S Yao - Lab on a Chip, 2023 - pubs.rsc.org
Recent advances in CRISPR-based biotechnologies have greatly expanded our capabilities
to repurpose CRISPR for the development of molecular diagnostic systems. The key …

Sensitive detection of multiple blood biomarkers via immunomagnetic exosomal PCR for the diagnosis of Alzheimer's disease

S Hu, L Zhang, Y Su, X Liang, J Yang, Q Luo… - Science …, 2024 - science.org
Blood exosomes are emerging as potential biomarkers for diagnosing brain diseases such
as Alzheimer's disease (AD). There is currently a lack of an ultrasensitive technology for …

A polyaniline functionalized NiFeP nanosheet array-based electrochemical immunosensor using Au/Cu 2 O nanocubes as a signal amplifier for the detection of SARS …

L Bai, Y Shi, X Zhang, X Cao, J Jia, H Shi, W Lu - Analyst, 2023 - pubs.rsc.org
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged as a novel pathogen in …

Microfluidic systems for the analysis of blood‐derived molecular biomarkers

OG Chavez‐Pineda, R Rodriguez‐Moncayo… - …, 2022 - Wiley Online Library
Biomarkers are relevant indicators of the physiological state of an individual. Although
biomarkers can be found in diseased tissue and different biofluids, sampling from blood …

Recent advances in centrifugal microfluidics for point-of-care testing

H Yuan, Z Miao, C Wan, J Wang, J Liu, Y Li, Y **ao… - Lab on a Chip, 2025 - pubs.rsc.org
Point-of-care testing (POCT) holds significant importance in the field of infectious disease
prevention and control, as well as personalized precision medicine. The emerging …

Programmable‐Modulated Ultrasonic Transducer Array for Contactless Detection of Viral RNAs

Y Luo, M Zhou, L Wang, C Fan, T Xu, X Zhang - Small Methods, 2023 - Wiley Online Library
The current polymerase chain reactions‐based nucleic acid tests for large‐scale infectious
disease diagnosis are always lab‐dependent and generate large amounts of highly …

Development of an innovative quantification assay based on aptamer sandwich and isothermal dumbbell exponential amplification

M Aubret, M Savonnet, P Laurent, Y Roupioz… - Analytical …, 2022 - ACS Publications
Detecting blood biomarkers such as proteins with high sensitivity and specificity is of the
utmost importance for early and reliable disease diagnosis. As molecular probes, aptamers …

A nanogap-enhanced SERS nanotag–based lateral flow assay for ultrasensitive and simultaneous monitoring of SARS-CoV-2 S and NP antigens

X Liu, X Yang, C Wang, Q Liu, Y Ding, S Xu, G Wang… - Microchimica Acta, 2024 - Springer
A lateral flow assay (LFA) strip based on dual 5, 5′-dithiobis-(2-nitrobenzoic acid)(DTNB)–
encoded satellite Fe3O4@ Au (Mag@ Au) SERS tags with nanogap is reported for …

[HTML][HTML] A portable, low-cost and high-throughput electrochemical impedance spectroscopy device for point-of-care biomarker detection

X Ye, T Jiang, Y Ma, D To, S Wang, J Chen - Biosensors and Bioelectronics …, 2023 - Elsevier
This paper presents a portable, fast and accurate electrochemical impedance spectroscopy
(EIS) device with 8-well interdigitated electrode chips for biomarker detection. The design …