Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is a heme enzyme that catalyzes the
oxidation of L-tryptophan. Functionally, IDO1 has played a pivotal role in cancer immune …

The potential contribution of chronic inflammation to the development of neuropsychiatric
disorders such as major depression has received increasing attention. Elevated biomarkers …

Most life science processes involve, at the atomic scale, recognition between two molecules.
The prediction of such interactions at the molecular level, by so-called docking software, is a …

Various pathologies of the central nervous system (CNS) are accompanied by alterations in
tryptophan metabolism. The main metabolic route of tryptophan degradation is the …

Tryptophan catabolism mediated by indoleamine 2, 3-dioxygenase (IDO1) is an important
mechanism of peripheral immune tolerance contributing to tumoral immune resistance, and …

In most countries, healthcare service budgets are not likely to support the current explosion
in the cost of new oncology drugs. Repurposing the large arsenal of approved, non …

The prediction of binding modes (BMs) occurring between a small molecule and a target
protein of biological interest has become of great importance for drug development. The …

Data suggest that cytokines released during the inflammatory response target subcortical
structures including the basal ganglia as well as dopamine function to acutely induce …

Even in the 21st century, studies aimed at characterizing the pathological paradigms
associated with the development and progression of central nervous system diseases are …

Since the discovery of indoleamine 2, 3-dioxygenase 1 (IDO1) as an attractive target for
anticancer therapy in 2003, the search for inhibitors has been intensely pursued both in …