Mitochondrial impairment: A common motif in neuropsychiatric presentation? The link to the tryptophan–kynurenine metabolic system

M Tanaka, Á Szabó, E Spekker, H Polyák, F Tóth… - Cells, 2022 - mdpi.com
Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

Manganese-induced neurotoxicity: new insights into the triad of protein misfolding, mitochondrial impairment, and neuroinflammation

DS Harischandra, S Ghaisas, G Zenitsky… - Frontiers in …, 2019 - frontiersin.org
Occupational or environmental exposure to manganese (Mn) can lead to the development of
“Manganism,” a neurological condition showing certain motor symptoms similar to …

A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion

N Scott, M Prigge, O Yizhar, T Kimchi - Nature, 2015 - nature.com
It is commonly assumed, but has rarely been demonstrated,, that sex differences in
behaviour arise from sexual dimorphism in the underlying neural circuits,. Parental care is a …

Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes

DA Gonzalez-Carter, BF Leo, P Ruenraroengsak… - Scientific reports, 2017 - nature.com
Silver nanoparticles (AgNP) are known to penetrate into the brain and cause neuronal
death. However, there is a paucity in studies examining the effect of AgNP on the resident …

Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of Parkinson's disease

N Panicker, H Saminathan, H **, M Neal… - Journal of …, 2015 - Soc Neuroscience
Sustained neuroinflammation mediated by resident microglia is recognized as a key
pathophysiological contributor to many neurodegenerative diseases, including Parkinson's …

Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

N Giguère, B Delignat-Lavaud, F Herborg… - PLoS …, 2019 - journals.plos.org
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Rare genetic …

Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress …

N Singh, V Lawana, J Luo, P Phong, A Abdalla… - Neurobiology of …, 2018 - Elsevier
The organophosphate (OP) pesticide chlorpyrifos (CPF), used in agricultural settings,
induces developmental and neurological impairments. Recent studies using in vitro cell …

Current understanding of methamphetamine-associated dopaminergic neurodegeneration and psychotoxic behaviors

EJ Shin, DK Dang, TV Tran, HQ Tran, JH Jeong… - Archives of Pharmacal …, 2017 - Springer
Clinical and preclinical studies have indicated that chronic methamphetamine (MA) use is
associated with extensive neurodegeneration, psychosis, and cognitive impairment …

Role of mitochondria in methamphetamine-induced dopaminergic neurotoxicity: involvement in oxidative stress, neuroinflammation, and pro-apoptosis—a review

EJ Shin, HQ Tran, PT Nguyen, JH Jeong, SY Nah… - Neurochemical …, 2018 - Springer
Abstract Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with
dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies …

Ellagic acid protects dopamine neurons via inhibition of NLRP3 inflammasome activation in microglia

X He, Y Zhou, S Sheng, J Li, G Wang… - … Medicine and Cellular …, 2020 - Wiley Online Library
Neuroinflammation plays a crucial role in the pathological process of Parkinson's disease
(PD). Nod‐like receptor protein 3 (NLRP3) inflammasome was highly located in microglia …