Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Gap junctions consist of arrays of intercellular channels that enable adjacent cells to
communicate both electrically and metabolically. Gap junctions have a wide diversity of …

Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Connexins are the primary components of gap junctions, providing direct links between cells
under many physiological processes. Here, we demonstrate that in addition to this canonical …

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate
direct intercellular communication, a critical feature for the development, function, and …

Gap Junction (GJ) channels, including the most common Connexin 43 (Cx43), have
fundamental roles in excitable tissues by facilitating rapid transmission of action potentials …

Connexins and pannexins are two families of large-pore channel forming proteins that are
capable of passing small signaling molecules. While connexins serve the seminal task of …