The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
S Cambier, M Gouwy, P Proost - Cellular & Molecular Immunology, 2023 - nature.com
Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …
of directional migration and activation of leukocytes. CXCL8 is the most potent human …
RNA regulons: coordination of post-transcriptional events
JD Keene - Nature Reviews Genetics, 2007 - nature.com
Recent findings demonstrate that multiple mRNAs are co-regulated by one or more
sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability …
sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability …
MCP-1: chemoattractant with a role beyond immunity: a review
BACKGROUND: Monocyte Chemoattractant Protein (MCP)-1, a potent monocyte attractant,
is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G …
is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G …
Update on glucocorticoid action and resistance
Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …
molecules that have been optimized to target activity to the lung and minimize systemic …
Anti-Inflammatory and Antioxidant Effects of Anthocyanins of Trifolium pratense (Red Clover) in Lipopolysaccharide-Stimulated RAW-267.4 Macrophages
Red clover (Trifolium pratense) possesses various dietary compounds that improve human
health. However, the functions of anthocyanins in red clover remain unclear. Here we …
health. However, the functions of anthocyanins in red clover remain unclear. Here we …
Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases
Glucocorticoids are widely used to treat various inflammatory lung diseases. Acting via the
glucocorticoid receptor (GR), they exert clinical effects predominantly by modulating gene …
glucocorticoid receptor (GR), they exert clinical effects predominantly by modulating gene …
Mechanisms of eosinophilia in the pathogenesis of hypereosinophilic disorders
SJ Ackerman, BS Bochner - Immunology and allergy clinics of North …, 2007 - Elsevier
The increased numbers of activated eosinophils in the blood and tissues that typically
accompany hypereosinophilic disorders result from a variety of mechanisms. Exciting …
accompany hypereosinophilic disorders result from a variety of mechanisms. Exciting …
Development of mammalian ovary
Obesity is an ongoing pandemic and serves as a causal factor of a wide spectrum of
metabolic diseases including diabetes, fatty liver disease, and cardiovascular disease. Much …
metabolic diseases including diabetes, fatty liver disease, and cardiovascular disease. Much …
Overview of the mechanisms regulating chemokine activity and availability
A Mortier, J Van Damme, P Proost - Immunology letters, 2012 - Elsevier
Physiological leukocyte homing and extravasation of leukocytes during inflammatory
processes is directed by a number of proteins including adhesion molecules, proteases …
processes is directed by a number of proteins including adhesion molecules, proteases …
HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models
G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously
expressed in human tissues, that orchestrates target RNA maturation and processing both in …
expressed in human tissues, that orchestrates target RNA maturation and processing both in …