Mechanism of intranasal drug delivery directly to the brain
Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging
populations, which greatly contributes to increasing healthcare costs. The development of …
populations, which greatly contributes to increasing healthcare costs. The development of …
Evaluation of recent intranasal drug delivery systems to the central nervous system
TP Crowe, WH Hsu - Pharmaceutics, 2022 - mdpi.com
Neurological diseases continue to increase in prevalence worldwide. Combined with the
lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a …
lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a …
Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human …
LM Baak, N Wagenaar, NE van der Aa… - The Lancet …, 2022 - thelancet.com
Background Perinatal arterial ischaemic stroke (PAIS) is an important cause of
neurodevelopmental disabilities. In this first-in-human study, we aimed to assess the …
neurodevelopmental disabilities. In this first-in-human study, we aimed to assess the …
Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy
Objective To assess feasibility and safety of providing autologous umbilical cord blood
(UCB) cells to neonates with hypoxic-ischemic encephalopathy (HIE). Study design We …
(UCB) cells to neonates with hypoxic-ischemic encephalopathy (HIE). Study design We …
Preterm brain injury, antenatal triggers, and therapeutics: timing is key
DRMG Ophelders, R Gussenhoven, L Klein… - Cells, 2020 - mdpi.com
With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …
Intranasal delivery of mesenchymal stem cells-derived extracellular vesicles for the treatment of neurological diseases
Neurological disorders are diseases of the central nervous system (CNS), characterized by
a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem …
a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem …
Intranasally administered exosomes from umbilical cord stem cells have preventive neuroprotective effects and contribute to functional recovery after perinatal brain …
G Thomi, M Joerger-Messerli, V Haesler, L Muri… - Cells, 2019 - mdpi.com
Perinatal brain injury (PBI) in preterm birth is associated with substantial injury and
dysmaturation of white and gray matter, and can lead to severe neurodevelopmental deficits …
dysmaturation of white and gray matter, and can lead to severe neurodevelopmental deficits …
Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin
N Boukelmoune, GS Chiu, A Kavelaars… - Acta neuropathologica …, 2018 - Springer
Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells
via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs …
via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs …
Metformin prevents cisplatin-induced cognitive impairment and brain damage in mice
W Zhou, A Kavelaars, CJ Heijnen - PloS one, 2016 - journals.plos.org
Rationale Chemotherapy-induced cognitive impairment, also known as 'chemobrain', is now
widely recognized as a frequent adverse side effect of cancer treatment that often persists …
widely recognized as a frequent adverse side effect of cancer treatment that often persists …
Perinatal hyperoxia and developmental consequences on the lung‐brain axis
Approximately 11.1% of all newborns worldwide are born preterm. Improved neonatal
intensive care significantly increased survival rates over the last decades but failed to …
intensive care significantly increased survival rates over the last decades but failed to …