Mechanism of intranasal drug delivery directly to the brain

TP Crowe, MHW Greenlee, AG Kanthasamy, WH Hsu - Life sciences, 2018 - Elsevier
Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging
populations, which greatly contributes to increasing healthcare costs. The development of …

Evaluation of recent intranasal drug delivery systems to the central nervous system

TP Crowe, WH Hsu - Pharmaceutics, 2022 - mdpi.com
Neurological diseases continue to increase in prevalence worldwide. Combined with the
lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a …

Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human …

LM Baak, N Wagenaar, NE van der Aa… - The Lancet …, 2022 - thelancet.com
Background Perinatal arterial ischaemic stroke (PAIS) is an important cause of
neurodevelopmental disabilities. In this first-in-human study, we aimed to assess the …

Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy

CM Cotten, AP Murtha, RN Goldberg, CA Grotegut… - The Journal of …, 2014 - Elsevier
Objective To assess feasibility and safety of providing autologous umbilical cord blood
(UCB) cells to neonates with hypoxic-ischemic encephalopathy (HIE). Study design We …

Preterm brain injury, antenatal triggers, and therapeutics: timing is key

DRMG Ophelders, R Gussenhoven, L Klein… - Cells, 2020 - mdpi.com
With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …

Intranasal delivery of mesenchymal stem cells-derived extracellular vesicles for the treatment of neurological diseases

S Herman, I Fishel, D Offen - Stem Cells, 2021 - academic.oup.com
Neurological disorders are diseases of the central nervous system (CNS), characterized by
a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem …

Intranasally administered exosomes from umbilical cord stem cells have preventive neuroprotective effects and contribute to functional recovery after perinatal brain …

G Thomi, M Joerger-Messerli, V Haesler, L Muri… - Cells, 2019 - mdpi.com
Perinatal brain injury (PBI) in preterm birth is associated with substantial injury and
dysmaturation of white and gray matter, and can lead to severe neurodevelopmental deficits …

Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

N Boukelmoune, GS Chiu, A Kavelaars… - Acta neuropathologica …, 2018 - Springer
Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells
via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs …

Metformin prevents cisplatin-induced cognitive impairment and brain damage in mice

W Zhou, A Kavelaars, CJ Heijnen - PloS one, 2016 - journals.plos.org
Rationale Chemotherapy-induced cognitive impairment, also known as 'chemobrain', is now
widely recognized as a frequent adverse side effect of cancer treatment that often persists …

Perinatal hyperoxia and developmental consequences on the lung‐brain axis

S Obst, J Herz, MA Alejandre Alcazar… - Oxidative medicine …, 2022 - Wiley Online Library
Approximately 11.1% of all newborns worldwide are born preterm. Improved neonatal
intensive care significantly increased survival rates over the last decades but failed to …