Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis

KA Staats, DR Borchelt, MG Tansey… - Molecular …, 2022 - Springer
Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in
which many processes are detected including (neuro) inflammation. Many drugs have been …

Blood biomarkers in ALS: challenges, applications and novel frontiers

E Sturmey, A Malaspina - Acta Neurologica Scandinavica, 2022 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease among
adults. With diagnosis reached relatively late into the disease process, extensive motor cell …

T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression

S Yazdani, C Seitz, C Cui, A Lovik, L Pan… - Nature …, 2022 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving
neuroinflammation and T cell infiltration in the central nervous system. However, the …

Mesenchymal stromal cell therapies for neurodegenerative diseases

NP Staff, DT Jones, W Singer - Mayo Clinic Proceedings, 2019 - Elsevier
Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of
medical conditions. Over the past decade, there has been considerable excitement about …

The CD14+HLA-DRlo/neg Monocyte: An Immunosuppressive Phenotype That Restrains Responses to Cancer Immunotherapy

AE Mengos, DA Gastineau, MP Gustafson - Frontiers in immunology, 2019 - frontiersin.org
Recent successes in cancer immunotherapy have been tempered by sub-optimal clinical
responses in the majority of patients. The impaired anti-tumor immune responses observed …

Biomarkers in motor neuron disease: a state of the art review

NS Verber, SR Shepheard, M Sassani… - Frontiers in …, 2019 - frontiersin.org
Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

Peripheral proinflammatory Th1/Th17 immune cell shift is linked to disease severity in amyotrophic lateral sclerosis

M **, R Günther, K Akgün, A Hermann, T Ziemssen - Scientific reports, 2020 - nature.com
Neuroinflammation is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS),
but only limited data are available on systematic peripheral and central immune cell profiles …

The peripheral immune system and amyotrophic lateral sclerosis

PA McCombe, JD Lee, TM Woodruff… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that is defined by
loss of upper and lower motor neurons, associated with accumulation of protein aggregates …

Current state and future directions in the diagnosis of amyotrophic lateral sclerosis

M Vidovic, LH Müschen, S Brakemeier, G Machetanz… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …

[HTML][HTML] NK cells associate with ALS in a sex-and age-dependent manner

BJ Murdock, JP Famie, CE Piecuch, KD Pawlowski… - JCI insight, 2021 - ncbi.nlm.nih.gov
NK cells are innate immune cells implicated in ALS; whether NK cells impact ALS in a sex-
and age-specific manner was investigated. Herein, NK cells were depleted in male and …