Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis
Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in
which many processes are detected including (neuro) inflammation. Many drugs have been …
which many processes are detected including (neuro) inflammation. Many drugs have been …
Blood biomarkers in ALS: challenges, applications and novel frontiers
E Sturmey, A Malaspina - Acta Neurologica Scandinavica, 2022 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease among
adults. With diagnosis reached relatively late into the disease process, extensive motor cell …
adults. With diagnosis reached relatively late into the disease process, extensive motor cell …
T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving
neuroinflammation and T cell infiltration in the central nervous system. However, the …
neuroinflammation and T cell infiltration in the central nervous system. However, the …
Mesenchymal stromal cell therapies for neurodegenerative diseases
Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of
medical conditions. Over the past decade, there has been considerable excitement about …
medical conditions. Over the past decade, there has been considerable excitement about …
The CD14+HLA-DRlo/neg Monocyte: An Immunosuppressive Phenotype That Restrains Responses to Cancer Immunotherapy
AE Mengos, DA Gastineau, MP Gustafson - Frontiers in immunology, 2019 - frontiersin.org
Recent successes in cancer immunotherapy have been tempered by sub-optimal clinical
responses in the majority of patients. The impaired anti-tumor immune responses observed …
responses in the majority of patients. The impaired anti-tumor immune responses observed …
Biomarkers in motor neuron disease: a state of the art review
NS Verber, SR Shepheard, M Sassani… - Frontiers in …, 2019 - frontiersin.org
Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …
Peripheral proinflammatory Th1/Th17 immune cell shift is linked to disease severity in amyotrophic lateral sclerosis
Neuroinflammation is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS),
but only limited data are available on systematic peripheral and central immune cell profiles …
but only limited data are available on systematic peripheral and central immune cell profiles …
The peripheral immune system and amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that is defined by
loss of upper and lower motor neurons, associated with accumulation of protein aggregates …
loss of upper and lower motor neurons, associated with accumulation of protein aggregates …
Current state and future directions in the diagnosis of amyotrophic lateral sclerosis
M Vidovic, LH Müschen, S Brakemeier, G Machetanz… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …
[HTML][HTML] NK cells associate with ALS in a sex-and age-dependent manner
BJ Murdock, JP Famie, CE Piecuch, KD Pawlowski… - JCI insight, 2021 - ncbi.nlm.nih.gov
NK cells are innate immune cells implicated in ALS; whether NK cells impact ALS in a sex-
and age-specific manner was investigated. Herein, NK cells were depleted in male and …
and age-specific manner was investigated. Herein, NK cells were depleted in male and …