Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …

Abstract Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a
trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase …

How neuronal connections are established and organized into functional networks
determines brain function. In the mammalian cerebral cortex, different classes of GABAergic …

The postsynaptic density (PSD) is a massive protein complex, critical for synaptic strength
and plasticity in excitatory neurons. Here, the scaffolding protein PSD-95 plays a crucial role …

INTRODUCTION Synapses are fundamental structural and functional units within neural
circuits, where they define the connectivity between neurons and provide avenues for …

Metastasis causes most cancer-related deaths, and one poorly understood aspect of
metastatic cancer is the adaptability of cells from a primary tumor to create new niches and …

Abstract 'A disintegrin and metalloproteases'(ADAMs) are a family of transmembrane
proteins with diverse functions in multicellular organisms. About half of the ADAMs are active …

The primate neocortex exerts high cognitive ability and strong information processing
capacity. Here, we establish a single-cell RNA sequencing dataset of 133,454 macaque …

Physiological functioning and homeostasis of the brain rely on finely tuned synaptic
transmission, which involves nanoscale alignment between presynaptic neurotransmitter …