Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …

Tissue-resident memory T (T RM) cells positively correlate with cancer survival, but the anti-
tumor mechanisms underlying this relationship are not understood. This review reconciles …

Fundamental discoveries in many aspects of mammalian physiology have been made using
laboratory mice as research models. These studies have been facilitated by the genetic …

Fundamental to mammalian intrinsic and innate immune defenses against pathogens is the
production of Type I and Type II interferons, such as IFN-β and IFN-γ, respectively. The …

Uropathogenic E. coli (UPEC) is a primary organism responsible for urinary tract infections
and a common cause of sepsis. Microbially experienced laboratory mice, generated by …

Tissue-resident memory T (Trm) cells are a subset of T cells maintained throughout life
within nonlymphoid tissues without significant contribution from circulating memory T cells …

Individual tissues have distinct antiviral properties garnered through various mechanisms,
including physical characteristics, tissue-resident immune cells and commensal organisms …

Immune cells residing at the gingiva experience diverse and unique signals, tailoring their
functions to enable them to appropriately respond to immunological challenges and …

In mucosal barriers, tissue cells and leukocytes collaborate to form specialized niches that
support host-microbiome symbiosis. Understanding the spatial organization of these barriers …

Trm cells are sequestered at barrier tissues as a swift first line defense against peripheral
reinfections in both antigen dependent and antigen independent bystander modes. Trm …