Cells respond to external stimuli by rapidly remodeling their actin cytoskeleton. At the heart
of this function lies the intricately controlled regulation of individual filaments. The barbed …

Cell division is a fundamental but complex process that gives rise to two daughter cells. It
includes an ordered set of events, altogether called “the cell cycle”, that culminate with …

The mechanisms by which cells destabilize and rapidly disassemble filamentous actin
networks have remained elusive; however, Coronin, Cofilin and AIP1 have been implicated …

Dominant mutations in tyrosyl-tRNA synthetase (YARS1) and six other tRNA ligases cause
Charcot-Marie-Tooth peripheral neuropathy (CMT). Loss of aminoacylation is not required …

Abstract Inverted formin 2 (INF2) is a member of the formin family of actin assembly factors.
Dominant missense mutations in INF2 are linked to two diseases: focal segmental …

Cellular actin networks exhibit diverse filamentous architectures and turnover dynamics, but
how these differences are specified remains poorly understood. Here, we used multicolor …

In response to pheromone Saccharomyces cerevisiae extend a mating projection. This
process depends on the formation of polarized actin cables which direct secretion to the …

Actin regulators facilitate cell migration by controlling cell protrusion architecture and
dynamics. As the behavior of individual actin regulators becomes clear, we must address …

Srv2/CAP is a conserved actin-binding protein with important roles in driving cellular actin
dynamics in diverse animal, fungal, and plant species. However, there have been conflicting …

Sarcomeres, the fundamental contractile units of muscles, are conserved structures
composed of actin thin filaments and myosin thick filaments. How sarcomeres are formed …