Initial attachment to host intestinal mucosa after oral infection is one of the most important
stages during bacterial pathogenesis. Adhesive structures, widely present on the bacterial …

Bacteria of the genus Salmonella comprise a large and evolutionary related population of
zoonotic pathogens that can infect mammals, including humans and domestic animals …

Understanding the molecular parameters that regulate cross-species transmission and host
adaptation of potential pathogens is crucial to control emerging infectious disease. Although …

Abstract Initial stages of Salmonella Typhimurium infection involve a series of coordinated
events aimed at reaching, attaching to, and invading host cells. Virulence factors such as …

Pathogenic bacteria, such as enteropathogenic Escherichia coli (EPEC) and enterotoxigenic
E. coli (ETEC), cause diarrhea in mammals. In particular, E. coli colonizes and infects the …

Salmonella enterica has a wide diversity, with numerous serovars belonging to six different
subspecies with dynamic animal-host tropism. The FimH protein is the adhesin mediating …

Quorum sensing is used by bacteria to coordinate gene expression in response to
population density and involves the production, detection and response to extracellular …

For many biological processes such as ligand binding, enzymatic catalysis, or protein
folding, allosteric regulation of protein conformation and dynamics is fundamentally …

It was suggested that minor differences in the structure of FimH are most likely associated
with differences in its adhesion specificities and may determine the tropism of various …

We have recently shown that Salmonella Gallinarum type 1 fimbriae with endogenous
mannose-resistant (MR) variant of the FimH protein increase systemic dissemination of S …