Metabolomics: beyond biomarkers and towards mechanisms
Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …
The evolving metabolic landscape of chromatin biology and epigenetics
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …
inputs—which include both nutrient availability as a result of diet and growth factor signalling …
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
JSL Yu, W Cui - Development, 2016 - journals.biologists.com
Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) constitute the core components of the …
mammalian target of rapamycin (mTOR) constitute the core components of the …
Kynurenine pathway of tryptophan metabolism: regulatory and functional aspects
AAB Badawy - International journal of tryptophan research, 2017 - journals.sagepub.com
Regulatory and functional aspects of the kynurenine (K) pathway (KP) of tryptophan (Trp)
degradation are reviewed. The KP accounts for~ 95% of dietary Trp degradation, of which …
degradation are reviewed. The KP accounts for~ 95% of dietary Trp degradation, of which …
Mitochondria as signaling organelles control mammalian stem cell fate
Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts
High-grade serous carcinoma has a poor prognosis, owing primarily to its early
dissemination throughout the abdominal cavity. Genomic and proteomic approaches have …
dissemination throughout the abdominal cavity. Genomic and proteomic approaches have …
Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics
Novel metabolites distinct from canonical pathways can be identified through the integration
of three cheminformatics tools: BinVestigate, which queries the BinBase gas …
of three cheminformatics tools: BinVestigate, which queries the BinBase gas …
Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids
Z Ai, B Niu, Y Yin, L **ang, G Shi, K Duan, S Wang… - Cell Research, 2023 - nature.com
Studies of cultured embryos have provided insights into human peri-implantation
development. However, detailed knowledge of peri-implantation lineage development as …
development. However, detailed knowledge of peri-implantation lineage development as …
The impact of cellular metabolism on chromatin dynamics and epigenetics
The substrates used to modify nucleic acids and chromatin are affected by nutrient
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …
Metabolomics activity screening for identifying metabolites that modulate phenotype
Metabolomics, in which small-molecule metabolites (the metabolome) are identified and
quantified, is broadly acknowledged to be the omics discipline that is closest to the …
quantified, is broadly acknowledged to be the omics discipline that is closest to the …