The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

Macroautophagy/autophagy is a conserved transport pathway where targeted structures are
sequestered by phagophores, which mature into autophagosomes, and then delivered into …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Accumulation of amyloid β-peptide (Aβ) is a driver of Alzheimer's disease (AD). Amyloid
precursor protein (App) knock-in mouse models recapitulate AD-associated Aβ pathology …

Endoplasmic reticulum (ER) stress is thought to activate autophagy via unfolded protein
response (UPR)-mediated transcriptional up-regulation of autophagy machinery …

The neuronal ceroid lipofuscinoses (NCLs), also referred to as Batten disease, are a family
of neurodegenerative diseases that affect all age groups and ethnicities around the globe. At …

Mutations in the GDAP1 gene cause Charcot–Marie–Tooth (CMT) neuropathy. GDAP1 is an
atypical glutathione S-transferase (GST) of the outer mitochondrial membrane and the …

Background Lipophagy is an autophagic process, which delivers the intracellular lipid
droplets to the lysosomes for degradation. Recent studies revealed that the impairment of …

Autophagy is closely related to the growth and drug resistance of cancer cells, and
autophagy related 4B (ATG4B) performs a crucial role in the process of autophagy. The long …

ABSTRACT CASP4/caspase-11-dependent inflammasome activation is important for the
clearance of various Gram-negative bacteria entering the host cytosol. Additionally, CASP4 …