The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X **e… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

The basic properties of gold nanoparticles and their applications in tumor diagnosis and treatment

X Bai, Y Wang, Z Song, Y Feng, Y Chen… - International journal of …, 2020 - mdpi.com
Gold nanoparticles (AuNPs) have been widely studied and applied in the field of tumor
diagnosis and treatment because of their special fundamental properties. In order to make …

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Z Zhou, J Song, L Nie, X Chen - Chemical society reviews, 2016 - pubs.rsc.org
The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the
efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of …

Aptamer-based targeted therapy

G Zhu, X Chen - Advanced drug delivery reviews, 2018 - Elsevier
Precision medicine holds great promise to harness genetic and epigenetic cues for targeted
treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative …

Isothermal amplification of nucleic acids

Y Zhao, F Chen, Q Li, L Wang, C Fan - Chemical reviews, 2015 - ACS Publications
Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …

Self-assembling nucleic acid nanostructures functionalized with aptamers

A Krissanaprasit, CM Key, S Pontula… - Chemical …, 2021 - ACS Publications
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

Cancer diagnosis with DNA molecular computation

C Zhang, Y Zhao, X Xu, R Xu, H Li, X Teng, Y Du… - Nature …, 2020 - nature.com
Early and precise cancer diagnosis substantially improves patient survival. Recent work has
revealed that the levels of multiple microRNAs in serum are informative as biomarkers for …

Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

HM Meng, H Liu, H Kuai, R Peng, L Mo… - Chemical Society …, 2016 - pubs.rsc.org
The combination of nanostructures with biomolecules leading to the generation of functional
nanosystems holds great promise for biotechnological and biomedical applications. As a …

Construction of a multiple-aptamer-based DNA logic device on live cell membranes via associative toehold activation for accurate cancer cell identification

X Chang, C Zhang, C Lv, Y Sun, M Zhang… - Journal of the …, 2019 - ACS Publications
The ability to accurately identify and isolate cells is the cornerstone of precise disease
diagnosis and therapies. A single-step cell identification method based on logic analysis of …

DNA-based dynamic mimicry of membrane proteins for programming adaptive cellular interactions

J Li, K Xun, L Zheng, X Peng, L Qiu… - Journal of the American …, 2021 - ACS Publications
Cells sense and respond to the external environment, mainly through proteins presented on
the membrane where their expression and conformation are dynamically regulated via …