The interleukin-3 receptor alpha chain (IL-3Rα), more commonly referred to as CD123, is
widely overexpressed in various hematological malignancies, including acute myeloid …

One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged
symptoms termed long coronavirus disease (COVID), yet disease phenotypes and …

Granulocyte–macrophage colony-stimulating factor (GM-CSF), macrophage colony-
stimulating factor (M-CSF; also known as CSF1), granulocyte colony-stimulating factor (G …

Despite the considerable efficacy observed when targeting a dispensable lineage antigen,
such as CD19 in B cell acute lymphoblastic leukaemia,, the broader applicability of adoptive …

Successful treatment of acute myeloid leukemia (AML) with chimeric antigen receptor (CAR)
T cells is hampered by toxicity on normal hematopoietic progenitor cells and low CAR T cell …

Cytokines regulate immune responses by binding to cell surface receptors, including the
common subunit beta (βc), which mediates signaling for GM-CSF, IL-3, and IL-5. Despite …

Over 50 investigational monoclonal antibody (mAb) therapeutics are currently undergoing
evaluation in late-stage clinical studies, which is expected to drive a trend toward first …

The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains
poor, with conventional chemotherapeutic treatments often associated with unacceptable …

Targeted eradication of transformed or otherwise dysregulated cells using monoclonal
antibodies (mAb), antibody–drug conjugates (ADC), T cell engagers (TCE), or chimeric …

Aims Inflammation is a key driver of atherosclerosis and myocardial infarction (MI), and
beyond proteins and microRNAs (miRs), long noncoding RNAs (lncRNAs) have been …